Title:Trojan Microparticles : A Composite Nanoparticle Delivery System
Volume: 19
Issue: 4
Author(s): Shalu Shukla*Vinay Pandit
Affiliation:
- Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jwalaji Distt, Kangra H.P., 176031, India
- Chandigarh College of Pharmacy, Landran Mohali Punjab, 140307, India
Keywords:
Trojan microparticles, nanoparticles, nanocarriers, pharmaceutical applications, microparticulates system, sustained release, target drug delivery system.
Abstract: In recent years, microparticulate systems have drawn growing attention as a viable strategy
for delivering cells, proteins, and medications to target areas. The Nanoparticles-in-Microparticles
System (NiMS) is a drug delivery method that combines nano- and microparticles to deliver medications
or genes to particular bodily regions with precision. A promising method for achieving dual or
multiple functions inside a formulation is the development of nanoparticle-in-microparticle systems
(NiMS). NiMS comprises a microparticle (M.P.) matrix and one or more nanoparticles (N.P.s). The
N.P.s can be designed to provide specific functionality, such as targeted drug delivery or imaging,
while the M.P. matrix can be tailored to provide sustained release or protect the N.P.s from degradation.
NiMS offer several advantages over traditional formulations, including the ability to control release
profiles and achieve site-specific delivery. By combining different types of N.P.s and M.P.s, it is
possible to create formulations that release drugs at different rates or with different kinetics, allowing
for tailored treatment regimens. Additionally, by lowering off-target effects and boosting efficacy, the
site-specific targeting offered by NiMS can enhance the therapeutic index of medications. Microparticles
are small, micron-sized particles that can be loaded with therapeutic agents and designed to deliver
them to specific tissues in the body. The pharmaceutical sector is developing microparticulate delivery
systems for oral, pulmonary, and cutaneous administration. For instance, a promising strategy
for treating respiratory conditions, including asthma and chronic obstructive pulmonary disease, is the
development of inhalable microparticles (COPD). Moreover, the use of microparticles for topical drug
delivery is being studied, where they can be formulated into creams, gels, or patches for treating skin
disorders. The composition of microparticles is crucial for successful tissue regeneration because the
particles must be biocompatible and able to interact with the cells in the targeted tissue. In addition,
the size and shape of the particles can affect their behavior and how they interact with cells. Chemical
and biological sensors and devices, optical detectors, electronic components, and nanoscale production
depend on nanostructures because they offer unique properties, such as increased surface area and enhanced
reactivity, which can be exploited to create more efficient and effective devices.
