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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Commentary

Curcumin Supplementation and Vascular Health: Is Gut Microbiota Involved?

Author(s): Samuele Laudani, Federica Martina Di Domenico, Nadia Paladino, Ida Guerrera, Giuseppe Grosso* and Justyna Godos

Volume 29, Issue 25, 2023

Published on: 04 August, 2023

Page: [1971 - 1974] Pages: 4

DOI: 10.2174/1381612829666230726112255

Abstract

Curcumin is a polyphenol compound widely investigated for its potential health benefits. Clinical evidence from randomized controlled trials shows substantial positive effects in healthy individuals but contrasting results for patients with cardio-metabolic disorders. There is growing evidence that the gut microbiota may play a role in curcumin transformation and absorption of more bioactive compounds, suggesting that the baseline health status (or other unmeasured variables) may explain the observed variability of the results.

Keywords: Cardiovascular disease, Nox-2, nuclear factor kappa-B, tumor necrosis factor-alpha, bacteroidetes, matrix metalloproteinase 9.

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