Title:Role of LncRNAs in the Pathogenesis of Sepsis and their Clinical
Significance
Volume: 24
Issue: 7
Author(s): Yongpeng Yang, Jianping Zhang, Ruifeng Xu, Weikai Wang and Lin Wei*
Affiliation:
- Centre for Pediatric Emergency Unit 1, Gansu Provincial Maternity and Child-care Hospital, Gansu
Provincial Children's Medical Center, Lanzhou, Gansu, 730050, China
Keywords:
LncRNAs, sepsis, biomarker, diagnosis, multiple organ dysfunction syndrome, nucleotides.
Abstract: Sepsis is a fatal organ dysfunction caused by the host's uncontrolled
response to infection, with high morbidity and mortality. Early diagnosis and intervention
are the most effective methods to reduce the mortality due to sepsis. However, there is
still a lack of definite biomarkers or intervention targets for the diagnosis, evaluation,
prognosis, and treatment of sepsis. Long non-coding RNAs (lncRNAs) are a type of noncoding
transcript with a length ranging from 200 to 100,000 nucleotides. LncRNAs
mainly locate in the cytoplasm and nucleus and participate in various signaling pathways
related to inflammatory reactions and organ dysfunction. Recent studies have reported
that lncRNAs are involved in regulating the pathophysiological process of sepsis. Some
classical lncRNAs have been confirmed as promising biomarkers to evaluate the
severity and prognosis of sepsis. This review summarizes the mechanical studies on
lncRNAs in sepsis-induced acute lung, kidney, myocardial, and liver injuries, analyzes
the role of lncRNAs in the pathogenesis of sepsis, and explores the possibility of
lncRNAs as potential biomarkers and intervention targets for sepsis-induced multiple
organ dysfunction.
