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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Mini-Review Article

Synthetic and Clinical Perspectives of Evotaz: An Overview

Author(s): Sachin Puri, Tanuja T. Yadav, Mangilal Chouhan and Kapil Kumar*

Volume 24, Issue 4, 2024

Published on: 07 September, 2023

Page: [372 - 390] Pages: 19

DOI: 10.2174/1389557523666230707151553

Price: $65

Abstract

Viruses cause a variety of diseases in the human body. Antiviral agents are used to prevent the production of disease-causing viruses. These agents obstruct and kill the virus's translation and replication. Because viruses share the metabolic processes of the majority of host cells, finding targeted medicines for the virus is difficult. In the ongoing search for better antiviral agents, the USFDA approved EVOTAZ, a new drug discovered for the treatment of Human Immunodeficiency Virus (HIV). It is a once-daily (OD) fixed-dose combination of Cobicistat, a cytochrome P450 (CYP) enzyme inhibitor, and Atazanavir, a protease inhibitor. The combination drug was created in such a way that it can inhibit both CYP enzymes and proteases at the same time, resulting in the virus's death. The drug is not effective in children under the age of 18; however, it is still being studied for various parameters. This review article focuses on EVOTAZ's preclinical and clinical aspects, as well as its efficacy and safety profiles.

Keywords: HIV-1, Antiviral, Protease, Cytochrome P450, EVOTAZ, Atazanavir, Cobicistat

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Puri, S.; Ahmad, I.; Patel, H.; Kumar, K.; Juvale, K. Evaluation of oxindole derivatives as a potential anticancer agent against breast carcinoma cells: In vitro, in silico and molecular docking study. Toxicol in vitro. 2023, 86, 105517.;
b) Kumawat, K; Kaur, R.; Kumar, K. In-silico prediction of novel fused quinazoline based topoisomerase inhibitors as anticancer agents. Med. Chem., 2023, 19, 431-444.

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