Meta-Analysis

他汀类药物与肝癌发病率的关系:一项最新的荟萃分析

卷 31, 期 6, 2024

发表于: 17 July, 2023

页: [762 - 775] 页: 14

弟呕挨: 10.2174/0929867330666230701000400

open access plus

摘要

背景:先前的研究已经发现他汀类药物在预防肝癌方面的潜在作用。 目的:本研究旨在探讨不同类型他汀类药物对肝癌发病率的影响。 方法:系统检索PubMed、EBSCO、Web of Science和Cochrane Library数据库自成立至2022年7月的相关文章,探讨亲脂或亲水他汀类药物暴露与肝癌发病率之间的关系。主要结果是肝癌的发病率。 结果:本荟萃分析纳入了11篇文章。综合结果显示,与未暴露的队列相比,暴露于亲脂性他汀类药物(OR=0.54, p < 0.001)和亲水他汀类药物(OR=0.56, p < 0.001)的患者肝癌发病率降低。亚组分析显示,两种暴露于亲脂性(东方国家:OR=0.51, p < 0.001;西方国家:OR=0.59, p < 0.001)和亲水性(东方国家:OR=0.51, p < 0.001;西方国家:OR=0.66, p=0.019)他汀类药物降低了东西方国家的肝癌发病率,东方国家的降低最为显著。与氟伐他汀、西伐他汀和普伐他汀不同,阿托伐他汀(OR=0.55, p < 0.001)、辛伐他汀(OR=0.59, p < 0.001)、洛伐他汀(OR=0.51, p < 0.001)、匹伐他汀(OR=0.36, p=0.008)和瑞舒伐他汀(OR=0.60, p=0.027)能有效降低肝癌的发生率。 结论:亲脂性和亲水性他汀类药物都有助于预防肝癌。此外,其疗效受使用的区域和特定类型的他汀类药物的影响。

关键词: 肝癌,他汀类,亲脂性他汀类,亲水性他汀类,发病率,荟萃分析。

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