Title:Ionic Liquid Immobilized Pd Nanocatalysts for Chemoselective Reduction
of Aliphatic/Aromatic Nitro Compounds
Volume: 20
Issue: 12
Author(s): Om Prakash, Bhawana Jangir and Vivek Srivastava*
Affiliation:
- Mathematics and Basic Sciences: Chemistry, NIIT University, NH-8 Jaipur/Delhi Highway,
Neemrana, Rajasthan, Pin Code: 301705, India
Keywords:
Pd NPs, ionic liquid, nitro group reduction, amine, nitrolactone, aliskiren, Rasilez®, renin inhibitor.
Abstract: In this work, we have successfully synthesized four types of ionic liquid-mediated Pd
nanocatalysts and performed the physiochemical analysis of the developed Pd-based nanocatalysts using
a transmission electron microscope (TEM), X-Ray diffraction analysis (XRD), X-ray photoelectron
spectroscopy (XPS), and atomic absorption spectroscopy (AAS) analysis. The well-dispersed and
fine Pd nanoparticles were recorded in the ILPdNPs-4 catalytic system. We used this catalytic system
to reduce a series of aliphatic and aromatic compounds with nitro groups and developed various biologically
active amine molecules. In the continuation of the same, we also reduced nitrolactone, which
is considered one of the important starting materials for the synthesis of renin inhibitor aliskiren
(Tekturna®, and worldwide as Rasilez®). We also completed the catalyst stability test and recycled the
ILPdNPs-4 catalytic system for up to eight runs. No sign of metal leaching, Pd black formation, and
agglomeration was recorded during recycling runs.
