Title:Inflammatory Progression in Patients Undergoing Extracorporeal
Membrane Oxygenation
Volume: 24
Issue: 7
Author(s): Yan’er Yao, Huiyuan Kang, Ye Cheng, Xin Su*Bin Wang*
Affiliation:
- Department of Cardiology, the Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, Fujian, China
- Department of Cardiology, the Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, Fujian, China
Keywords:
Extracorporeal membrane oxygenation, inflammation, therapeutic strategy, systemic inflammatory response syndrome, mesenchymal stromal cell, inflammatory.
Abstract: Extracorporeal membrane oxygenation (ECMO) is identified as a novel
therapeutic strategy that offers short-term support to the metabolism of the heart and
lungs in humans. Recently, the clinical centers, which provide ECMO has increased
rapidly worldwide. The indications for the use of ECMO in daily clinical practice were
broadened dynamically. However, even with the widespread adoption of ECMO, it still
remains significant morbidity and mortality, and the underlying mechanisms are still not
elucidated. Notably, one of the vital complications during ECMO was proposed as the
inflammatory progression within the extracorporeal circulation. via the development of
inflammatory response, patients with ECMO may further suffer from systemic
inflammatory response syndrome (SIRS), posing serious risks to human health.
Recently, growing evidence confirmed that through exposure of blood into the ECMO
circuit could lead to the stimulation of the immune system which also facilitated the
inflammatory response and systemic impaired. In the current review, the pathological
development of inflammatory progression in patients with ECMO is well-listed.
Furthermore, the relationship between immune-related activation and the development
of inflammation is also summarized, which may further help us to decide the therapeutic
strategies in daily clinical practice.
