Title:An Insight into the Correlation between Phenolic Content and In vitro Antioxidant
Activity of Calocybe Indica Extracts
Volume: 20
Issue: 12
Author(s): Trung Hieu Le*, Thi Hong Chuong Nguyen, Quang Man Nguyen*, Lam Son Le, Thi Van Thi Tran, Dang Giang Chau Nguyen, Minh Nhung Nguyen, Xuan Anh Vu Ho, Viet Thang Nguyen, Chinh Chien Nguyen*Quyet Van Le*
Affiliation:
- University of Sciences, Hue University, Hue City 530000, Vietnam
- University of Medicine and Pharmacy, Hue University, Hue City 530000, Vietnam
- Center for Advanced Chemistry, Institute of Research and Development, Duy Tan University, Danang, 550000, Vietnam
- Faculty of Natural sciences, Duy Tan University, Danang, 550000, Vietnam
- Department of Materials Science and Engineering, Institute of Green Manufacturing Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea
Keywords:
Calocybe indica, antioxidant activity, HPLC, total phenolic content, total flavonoid content, extraction.
Abstract: Calocybe indica has been considered an essential herb, exhibiting a strong antioxidant capability.
To this point, the phenolic compounds could be the primary constituent inducing such high
activity. However, the phenolic-antioxidant activity correlation still needs to be understood. This
study attempted to shed light on the direct linkage between phenolic compounds and antioxidant activity
of the Vietnam-grown Calocybe indica for the first time. It turns out that the total amount of phenolic
content is 97.67 μg/g, which is exceptionally high in the methanol extract. Gallic acid, quercetin, quercitrin,
and hesperidin account for 49.02 ± 0.18 μg/g, 15.36 ± 0.24, 18.71 ± 0.32, and 14.58 ± 0.28 μg/g of such
activity, respectively. Such antioxidants result in an extraordinary performance in DPPH and ABTS evaluations.
Indeed, the total antioxidant capacity ranges from 59.67±0.78 to 91.26±1.57 mg GA/g or from
75.25±0.32 to 88.17±0.64 μmol AS/g, corresponding to the contents of phenolics from 24.92 ±0.24 to
35.28 ± 0.33 mg GAE/g. Furthermore, flavonoid compounds have been quantified to range from
14.63 ± 0.17 to 23.88 ± 0.10 mg QUE/g. These results imply the prominence of Calocybe indica for
biomedical applications.
