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Current Traditional Medicine

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ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

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Mini-Review Article

A Mini-Review on the Structural Characteristics and Anticancer Activity of Nagilactones

Author(s): Yuchen Xiao, Jianping Yong* and Canzhong Lu*

Volume 10, Issue 5, 2024

Published on: 13 July, 2023

Article ID: e070623217729 Pages: 7

DOI: 10.2174/2215083810666230607093151

Price: $65

Abstract

Natural products provide abundant resources for the development of new drugs. Podocarpus nagi is an arbor of Podocarpus L'Hér. ex Persoon. Its fruits, leaves, and roots exhibit a broad spectrum of pharmacological activities (such as antitumor, plant growth regulation, termite killing, and insect larval toxicity), which have been used in Yao folk for a long history. Nagilactone is one of the key components discovered in Podocarpus nagi, which has a variety of structures and a broad spectrum of antitumor activities. In this mini-review, the structures and spectral characteristics, together with the antitumor activities and the structure-activity relationships of nagilactones, are summarized by searching the database in order to provide detailed references for researchers to elucidate and modify their structures.

Keywords: Podocarpus nagi, chemical components, structure-activity relationships, nagilactone, traditional Chinese medicine, anticancer.

Graphical Abstract

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