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ISSN (Print): 2211-7385
ISSN (Online): 2211-7393

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Review Article

Neurotoxic Effects of Nanoparticles and their Pathogenesis

Author(s): Sunena*, Deepali Tomar and Sunil Jawla

Volume 12, Issue 1, 2024

Published on: 03 August, 2023

Page: [32 - 44] Pages: 13

DOI: 10.2174/2211738511666230602143628

Price: $65

Open Access Journals Promotions 2
Abstract

A recent study on the deployment of nanoparticles in the consumer and healthcare sectors has shown highly serious safety concerns. This is despite the fact that nanoparticles offer a vast array of applications and great promise. According to studies on how nanoparticles interact with neurons, the central nervous system experiences both negative and positive impacts central nervous system. With a maximum concentration of 0.1-1.0 wt.%, nanoparticles can be incorporated into materials to impart antibacterial and antiviral properties. Depending on the host or base materials utilised, this concentration may be transformed into a liquid phase release rate (leaching rate). For instance, nanoparticulate silver (Ag) or copper oxide (CuO)-filled epoxy resin exhibits extremely restricted release of the metal ions (Ag+ or Cu2+) into their surroundings unless they are physically removed or deteriorated. Nanoparticles are able to traverse a variety of barriers, including the blood-brain barrier (BBB) and skin, and are capable of penetrating biological systems and leaking into internal organs. In these circumstances, it is considered that the maximum drug toxicity test limit (10 g/ml), as measured in artificial cerebrospinal solution, is far lower than the concentration or dosage. As this is a fast-increasing industry, as the public exposure to these substances increases, so does their use. Thus, neurologists are inquisitive about how nanoparticles influence human neuronal cells in the central nervous system (CNS) in terms of both their potential benefits and drawbacks. This study will emphasise and address the significance of nanoparticles in human neuronal cells and how they affect the human brain and its activities

Keywords: Neurotoxicity, nanoparticles, blood-brain barrier, CNS oxidative stress, nanomedicines, neurons.

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