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Current Stem Cell Research & Therapy

Editor-in-Chief

ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Review Article

The Potential of Nanotechnology to Replace Cancer Stem Cells

Author(s): Muhammad Ammar Amanat, Anum Farrukh, Muhammad Umer Bin Muhammad Ishaq, Binyameen Bin Shafqat, Saqib Hussain Haidri, Rehab Amin, Rafia Sameen, Tahira Kamal, Muhammad Naeem Riaz, Waleed Quresh, Rabia Ikram, Ghulam Muhammad Ali, Sania Begum, Sajid Ali Khan Bangash, Imdad Kaleem, Shahid Bashir* and Sahir Hameed Khattak*

Volume 19, Issue 6, 2024

Published on: 20 July, 2023

Page: [820 - 831] Pages: 12

DOI: 10.2174/1574888X18666230601140700

Price: $65

Abstract

Stem cells, which were initially identified in the 1900s, are distinct cells with the potential to replenish themselves as well as differentiate into specialised cells with certain forms and functions. Cancer stem cells play a significant role in the growth and recurrence of the tumours and, similar to normal stem cells, are capable of proliferating and differentiating. Traditional cancer treatments are ineffective against cancer stem cells, which leads to tumour regrowth. Cancer stem cells are thought to emerge as a result of epithelial-to-mesenchymal transition pathways. Brain, prostate, pancreatic, blood, ovarian, lung, liver, melanomas, AML, and breast cancer stem cells are among the most prevalent cancer forms. This review aims to comprehend the possibility of using specific forms of nanotechnology to replace cancer stem cells. In terms of nanotechnology, magnetic nanoparticles can deliver medications, especially to the target region without harming healthy cells, and they are biocompatible. In order to kill glioma cancer stem cells, the gold nanoparticles bond with DNA and function as radio sensitizers. In contrast, liposomes can circulate and traverse biological membranes and exhibit high therapeutic efficacy, precise targeting, and better drug release. Similar to carbon nanotubes, grapheme, and grapheme oxide, these substances can be delivered specifically when utilized in photothermal therapy. Recent treatments including signaling pathways and indicators targeted by nanoparticles are being researched. Future research in nanotechnology aims to develop more effective and targeted medicinal approaches. The results of the current investigation also showed that this technology's utilization will improve medical therapy and treatment.

Keywords: Cancer stem cells, nanomaterials, nanotechnology, gold nano-particles, carbon nano-tubes, grapheme, and grapheme oxide.

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