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Mini-Review Article

绿色合成负载他莫昔芬的磁性纳米颗粒治疗乳腺癌的假设

卷 24, 期 5, 2024

发表于: 25 May, 2023

页: [537 - 546] 页: 10

弟呕挨: 10.2174/1566524023666230525104730

价格: $65

摘要

乳腺癌是全世界第二大死亡原因，不仅限于女性，也影响男性。对于雌激素受体阳性的乳腺癌，他莫昔芬几十年来一直被认为是最佳的治疗方法。然而，由于他莫昔芬的副作用，其使用仅限于高危人群，临床应用仅限于中危和/或低危人群。因此，有必要减少他莫昔芬的剂量，这可以通过将药物靶向乳腺癌细胞并限制其对身体其他部位的吸收来实现。在配方制备中使用的人工抗氧化剂被认为会增加人类患癌症和肝损伤的风险。目前的需要是从天然植物中探索生物高效抗氧化剂，因为它们更安全，而且还具有抗病毒、抗炎和抗癌的特性。该假设的目的是利用绿色化学方法制备负载他莫昔芬的聚乙二醇化NiO纳米颗粒，从而克服传统合成方法的毒性作用，靶向递送到乳腺癌细胞中。本研究的意义在于提出了一种环保、低成本、低多药耐药、可用于靶向治疗的NiO纳米颗粒的绿色合成方法。大蒜提取物含有一种有机硫化合物(大蒜素)，具有药物代谢、抗氧化和肿瘤生长抑制作用。在乳腺癌中，大蒜素使雌激素受体增敏，增加了他莫昔芬的抗癌功效，减少了场外毒性。因此，这种大蒜提取物可以作为还原剂和封盖剂。镍盐的使用可以帮助靶向递送到乳腺癌细胞，从而减少药物对不同器官的毒性。这种新颖的策略可能旨在以毒性较小的药物作为一种合适的治疗方式进行癌症管理。

关键词: 乳腺癌，绿色纳米技术，他莫昔芬，磁性金属纳米颗粒，抗氧化，靶向治疗。

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