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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Systematic Review Article

Influence of Renin-angiotensin System Inhibitors on the Treatment of Metastatic Renal Cancer

Author(s): Nikoo Saeedi, Saeide Mansoori, Fereshteh Asgharzadeh, Atena Soleimani, Samaneh Mollazadeh and Seyed Mahdi Hassanian*

Volume 29, Issue 18, 2023

Published on: 23 June, 2023

Page: [1459 - 1465] Pages: 7

DOI: 10.2174/1381612829666230524152108

Price: $65

Abstract

Background: Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) are mainly known as anti-hypertensive drugs. Recent evidence suggests their anti-tumor potential against renal cancer. More than one-fourth of patients present with metastasis on their first visit.

Objective: The purpose of the current study was to examine the potential clinical impact of ACEI/ARB on metastatic renal cell carcinoma (mRCC).

Methods: We searched through several online databases, including Pubmed, Scopus, Web of Science, and Embase, to find clinical studies that have investigated the association between treatment with ACEI/ARB and the survival of patients with mRCC. The hazard ratio (HR) and 95% confidence interval (95% CI) were utilized to assess the strength of the association.

Results: A total of 6 studies with a total number of 2,364 patients were found eligible for the final analysis. The HR for the relationship between ACEI/ARB use and overall survival (OS) showed patients undergoing treatment with ACEI/ARB to have higher OS than non-users (HR: 0.664, 95% CI 0.577-0.764, p = 0.000). Furthermore, the HR for the relationship between ACEI/ARB use and progression-free survival (PFS) showed patients undergoing treatment with ACEI/ARB to have higher PFS than non-users (HR: 0.734, 95% CI 0.695-0.794, p = 0.000).

Conclusion: The results of this review offer ACEI/ARB as a potential therapeutic option associated with improved survival outcomes in patients receiving anti-vascular endothelial growth factor therapy.

Keywords: Renin-angiotensin system inhibitors, metastatic renal cancer, angiotensin receptor blocker, angiotensin-converting enzyme inhibitor, ACEI/ARB, progression-free survival.

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