Title:A Comprehensive Review on Exosome: Recent Progress and Outlook
Volume: 12
Issue: 1
Author(s): Paras Agarwal, Adiba Anees, Raval Kavit Harsiddharay, Pranesh Kumar and Pushpendra Kumar Tripathi*
Affiliation:
- Institute of Pharmaceutical Sciences, University of Lucknow, Lucknow, India
- Department of Pharmaceutics, Institute
of Pharmaceutical Sciences, University of Lucknow, Lucknow, India
Keywords:
Exosomes, drug delivery, biogenesis, isolation, anticancer therapeutics, targeting methodology.
Abstract: Exosomes are intrinsic membrane-based vesicles that play a key role in both normal and
pathological processes. Since their discovery, exosomes have been investigated as viable drug delivery
systems and clinical indicators because of their magnitude and effectiveness in delivering biological
components to targeted cells. Exosome characteristics are biocompatible, prefer tumor recruitment, have
tunable targeting efficiency, and are stable, making them outstanding and eye-catching medication delivery
systems for cancer and other disorders. There is great interest in using cell-released tiny vesicles
that activate the immune system in the age of the fast development of cancer immunotherapy. Exosomes,
which are cell-derived nanovesicles, have a lot of potential for application in cancer immunotherapy
due to their immunogenicity and molecular transfer function. More significantly, exosomes can
transfer their cargo to specified cells and so affect the phenotypic and immune-regulation capabilities of
those cells. In this article, we summarize exosomes' biogenesis, isolation techniques, drug delivery, applications,
and recent clinical updates. The use of exosomes as drug-delivery systems for small compounds,
macromolecules, and nucleotides has recently advanced. We have tried to give holistic and exhaustive
pieces of information showcasing current progress and clinical updates of exosomes.
