Title:Evaluation of Coronary Artery Diffuse Calcification Stenosis by Corrected
Coronary Opacification Difference
Volume: 20
Author(s): Fangjie Shen, Jingfeng Huang, Qianjiang Ding, Quanliang Mao, Xinzhong Ruan and Yuning Pan*
Affiliation:
- Department of Radiology, Ningbo First Hospital, Ningbo, Zhejiang 315010, China
Keywords:
Corrected coronary opacification, Angiography, Diffuse, Calcific, Stenosis, CT.
Abstract:
Objectives:
The artifacts produced by calcification on coronary computed tomographic angiography (CCTA) have a great influence on the diagnosis of
coronary stenosis. The purpose of this study is to investigate the value of corrected coronary opacification (CCO) difference in the diagnosis of
stenosis in diffusely calcified coronary arteries (DCCAs).
Methods:
A total of 84 patients were enrolled. The CCO difference across the diffuse calcification was measured through CCTA. Coronary arteries were
grouped according to the extent of stenosis obtained by invasive coronary angiography (ICA). The Kruskal-Wallis H test was used to compare the
CCO differences between different groups and a receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of the
CCO difference.
Results:
Among the 84 patients, 58 patients had one DCCA, 14 patients had 2 DCCAs, and 12 patients had 3 DCCAs. A total of 122 coronary arteries were
examined, 16 showed no significant stenosis, 42 had <70% stenosis, and 64 had 70-99% stenosis. The median CCO differences among the 3
groups were 0.064, 0.117, and 0.176, respectively. There were significant differences between the group without stenosis and the group with
70-99% stenosis (H = -3.581, P = 0.001), and between the group with <70% stenosis and the group with 70-99% stenosis (H = -2.430, P = 0.045).
The area under the ROC curve was 0.681 and the optimal cut-off point was 0.292. Taking the ICA results as the gold standard, the sensitivity and
specificity for the diagnosis of ≥70% coronary stenosis with a cut-off point of 0.292 were 84.4% and 44.8%, respectively.
Conclusion:
CCO difference could be useful in the diagnosis of ≥70% severe coronary stenosis in DCCA. Through this non-invasive examination, the CCO
difference could be a reference for clinical treatment.
