To Explore the Putative Molecular Targets of Diabetic Nephropathy
and their Inhibition Utilizing Potential Phytocompounds

doi:10.2174/0929867330666230519112312
摘要

背景:本文综述了糖尿病肾病(DN)的分子靶点，筛选了可用于治疗的有效植物化合物，并强调了它们的作用机制。介绍：DN已成为临床高血糖症最常见的并发症之一，在疾病谱系中具有导致致命后果的个体特异性变化。多种病因包括氧化和亚硝化应激、多元醇途径的激活、炎性体的形成、细胞外基质(ECM)修饰、纤维化、足细胞功能和系膜细胞增殖的动态变化，这些都增加了DN的临床复杂性。目前的合成治疗方法缺乏靶向性，并且与不可避免的残留毒性和耐药性的发展有关。植物化合物提供了大量的新化合物，可以成为对抗DN的替代治疗方法。方法:从GOOGLE SCHOLAR、PUBMED、SCISEARCH等研究数据库中检索并筛选相关文献。从4895份出版物中，选择了最相关的出版物并纳入本文。结果：本研究综述了60多种最有前途的植物化学物质，并提供了它们的分子靶点，这些靶点对目前DN的治疗和相关研究具有药理意义。结论:这篇综述突出了那些最有前途的植物化合物，它们有可能成为新的更安全的天然治疗候选物，在临床水平上需要进一步关注。
关键词: 糖尿病肾病，2型糖尿病，肾脏，植物化合物，分子靶点，肾脏疾病。
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DOI https://dx.doi.org/10.2174/0929867330666230519112312	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
当代药物化学

探讨糖尿病肾病可能的分子靶点及其利用潜在植物化合物的抑制作用

摘要

Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.

Approaches to the Treatment of Chronic Inflammation

Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications

Chalcogen-modified nucleic acid analogues

当代药物化学

探讨糖尿病肾病可能的分子靶点及其利用潜在植物化合物的抑制作用

摘要

Call for Papers in Thematic Issues

Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.

Approaches to the Treatment of Chronic Inflammation

Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications

Chalcogen-modified nucleic acid analogues

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