Title:Tachykinins Play a Major Role in Micro and Macrovascular Complications
in Type 2 Diabetes Patients
Volume: 20
Issue: 3
Author(s): Faiqah Ramzan, Laila Kiran, Shumaila Noreen Malik and Muhammad Inamullah Malik*
Affiliation:
- Faculty of
Veterinary and Animal Sciences, Gomal University, Dera Ismail Khan, Pakistan
Keywords:
Diabetes, neuropeptides, neurosensory, tachykinins, vascular complications, neuropeptides.
Abstract: Diabetes Mellitus is a metabolic disorder, which is characterized by an increase in blood
glucose levels. The defects in the secretion or action of insulin are the major cause of diabetes. Increase
in the blood glucose level exerts a negative effect on the normal functions of the body organs
and this leads to the dysfunctions of cells and tissue and causes vascular complications in diabetic
patients. Several studies indicate that neuropeptides are released from the neurosensory cells
which are mainly known as tachykinins which provoke major vascular complications in diabetic
patients. Tachykinins are known as pro-inflammatory peptides which increase vascular complications
and vascular permeability. The duration and severity of diabetes disease increase the risk of
vascular complication in patients. The aim of this review is to elaborate the role of tachykinins in
microvascular and macrovascular complications in diabetic patients. The study concluded that
tachykinins increase micro and macrovascular complications in diabetic patients.
