Title:The Applications of CRISPR/Cas9 System for Urinary System Tumor
Volume: 23
Issue: 10
Author(s): Shulin Li, Yuqi Wu and Xiangwei Wang*
Affiliation:
- Department of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Department of Urology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, China
Keywords:
Urinary system tumor, CRISPR-Cas9, Gene editing, Gene therapy, Library screening, Genitourinary.
Abstract: Tumors of the urinary system include those in the urinary and reproductive systems, of
which tumors of the prostate, bladder, and kidney have the highest incidence. In recent years, due to
changes in dietary structure, prostate cancer has become the most common type of male genitourinary
system cancer. Furthermore, due to tobacco consumption, increases in industrialization, and
the age of the population, the incidence of bladder cancer in both males and females in both urban
and rural areas, has shown an increasing trend. The incidence and mortality of kidney cancer have
also increased and negatively affected the lives and health of all residents. While surgery, radiotherapy,
and chemotherapy have greatly improved the cure and survival rates of patients with urinary
tumors, we lack methods for early detection and effective long-term treatment. New tools and
methods for diagnosis and treatment are thus urgently needed. Recently, CRISPR/Cas9 has become
an efficient method to alter the genome in many organisms. It can be used to activate or inhibit gene
expression, which greatly facilitates the editing of targeted genes, both in vivo and in vitro. It provides
a powerful scientific research tool to analyze the mechanisms of disease occurrence and development
and to develop advanced targeted drug delivery. The diagnosis and treatment of human
tumors will consequently be improved as this technology will surely accelerate cancer research. In
this article, we discuss how CRISPR/Cas9 technology can be used to research and treat genitourinary
system tumors will consequently be improved as this technology will surely accelerate cancer
research. Here, we review the current applications of CRISPR/Cas9 technology for genitourinary
system tumor research and therapy.
