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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Application of Biomimetic Nanoparticles based on the Cell Membrane in Tumor Therapy

Author(s): Ya Gong and Jingbin Huang*

Volume 23, Issue 10, 2023

Published on: 15 May, 2023

Page: [907 - 920] Pages: 14

DOI: 10.2174/1568026623666230427114622

Price: $65

Abstract

Due to their unique biological functionality, nanocarriers can be designed to deliver various anti-tumor drugs in vivo, which has a wide and important application prospect in the field of tumor therapy. However, poor biosafety, short blood circulation time, and weak targeting ability still limit the application of nanoparticles in tumor therapy. In recent years, with the development of biomedicine, the biomimetic technology-based biomembrane-mediated drug delivery system is expected to achieve a breakthrough in tumor-targeted therapy due to low immunogenicity, tumor targeting, the adjustability and versatility of intelligent nanocarrier design. This paper mainly reviews the research process of different types of the cell membrane (erythrocyte membrane, cancer cell membrane, bacterial membrane, stem cell membrane, and hybrid membrane)-camouflaged nanoparticles in tumor therapy, as well as the challenges and development prospects in clinical application.

Keywords: Cell membrane, Biomimetic, Nanoparticles, Tumor therapy, Drug delivery, Biomedicine.

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