Title:Review of Magnetic Resonance Imaging and Post-processing for the Brain
Tumor-related Epilepsy Study
Volume: 20
Author(s): Reuben George, Li Sze Chow*, Kheng Seang Lim, Christine Audrey, Norlisah Ramli and Li-Kuo Tan
Affiliation:
- Department of Electrical and Electronic Engineering, Faculty of Engineering, Technology and Built Environment, UCSI University 1, Jalan Puncak
Menara Gading, Taman Connaught 56000, Cheras, Kuala Lumpur, Malaysia
Keywords:
Keywords: Glioma, MRI, Tumor-related epilepsy, Voxel-based morphometry, Lesion symptom mapping, Radiomics.
Abstract: 20% of brain tumor patients present with seizures at the onset of diagnosis, while a further 25-40% develop epileptic seizures as the tumor
progresses. Tumor-related epilepsy (TRE) is a condition in which the tumor causes recurring, unprovoked seizures. The occurrence of TRE differs
between patients, along with the effectiveness of treatment methods. Therefore, determining the tumor properties that correlate with epilepsy can
help guide TRE treatment. This article reviews the MRI sequences and image post-processing algorithms in the study of TRE. It focuses on
epilepsy caused by glioma tumors because it is the most common type of malignant brain tumor and it has a high prevalence of epilepsy. In
correlational TRE studies, conventional MRI sequences and diffusion-weighted MRI (DWI) are used to extract variables related to the tumor
radiological characteristics, called imaging factors. Image post-processing is used to correlate the imaging factors with the incidence of epilepsy.
The earlier studies of TRE used univariate and multivariate analysis to study the correlations between specific variables and incidence of epilepsy.
Later, studies used voxel-based morphometry and voxel lesion-symptom mapping. Radiomics has been recently used to post-process the images
for the study of TRE. This article will discuss the limitation of the existing imaging modalities and post-processing algorithms. It ends with some
suggestions and challenges for future TRE studies.
