Title:Purine Nucleosides and Analogues Bearing Chiral Substituents:
Medicinal Chemistry and Therapeutic Perspective
Volume: 31
Issue: 6
Author(s): Mikhail S. Drenichev*Valentina N. Borokh
Affiliation:
- Laboratory of Design and Synthesis of Biologically Active Compounds, Engelhardt Institute of Molecular
Biology, Russian Academy of Sciences, 32 Vavilova Str., Moscow, 119991, Russian Federation
Keywords:
Adenosine receptors, purinergic signaling, adenosine, chirality, enantiomeric, antiviral, transglycosylation, enzyme.
Abstract: Adenosine and its analogues play an important role as bioregulators of metabolic
processes in animal cells, affecting a variety of metabolic functions by acting
through the purinergic signaling system. Synthesis and structure-activity relationship for
some known purine nucleosides bearing chiral substituents are considered in this work.
These compounds represent a promising potential as drug prototypes for targeted therapy
of cancer, metabolic dysfunctions, and neuronal disorders due to their enhanced selectivity
to receptors of the purinergic signaling system. Derivatives of adenosine and guanosine
containing a chiral substituent also manifest antiviral activity.
