Title:Risk of Systemic Autoimmune Diseases with Antiarrhythmic Drugs in
Arrhythmia Patients: A Retrospective Cohort Study
Volume: 23
Issue: 14
Author(s): Jiun-Jie Lin, Hung-Yi Chen*, Mei-Chen Lin and Chung-Y. Hsu
Affiliation:
- Institute of Pharmacy, China Medical University, Taichung, Taiwan
- Department of
Pharmacy, China Medical University Hospital, Beikang Campus, Yunlin, Taiwan
Keywords:
Systemic autoimmune disease, antiarrhythmic drug, medication risk assessment, the asian population, Arrhythmia Patients, AAD.
Abstract:
Background: The risk factors for Systemic Autoimmune Disease (SAD)s with antiarrhythmic
drugs (AAD)s in arrhythmia patients are still unclear.
Aims: This study discussed these risk factors for SADs with AADs in arrhythmia patients.
Methods: This study was a retrospective cohort design and analyzed this relationship in an Asian population.
Patients without a prior diagnosis of SADs were identified from Taiwan's National Health Insurance
Research Database from January 1st , 2000, to December 31st , 2013. Cox regression models estimated the
hazard ratio (HR) with a 95% confidence interval (CI) of SAD.
Results: We estimated the data of participants aged ≧ 20 or ≦ 100 years old and free of SADs at baseline.
AAD users (n = 138376) had a significantly increased risk of SADs over non-AAD users. There was a
significantly higher risk of developing SADs in all age and sex categories. The patients who received
AADs, the autoimmune disease with the significantly higher risk was Systemic Lupus Erythematous
(SLE) (adjusted HR (aHR) 1.53, 95% CI, 1.04-2.26), Sjögren syndrome (SjS) (For adjusted HR (For aHR)
For 2.06 For, 95% CI, 1.59-2.66) and Rheumatoid Arthritis (RA) (aHR, 1.57, 95% CI, 1.26-1.94).
Conclusion: We concluded that there were statistical associations between AADs and SADs, and the
higher incidence was SLE, SjS and RA in arrhythmia patients.
