Title:The Role of Oxidative Stress in the Development and Therapeutic Intervention
of Hepatocellular Carcinoma
Volume: 23
Issue: 10
Author(s): Ying Liu, Chunhai Hao, Lei Li, Haiguang Zhang, Weina Zha, Longbin Ma, Li Chen*Jianhe Gan*
Affiliation:
- Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou, China
- Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou, China
Keywords:
Oxidative stress, hepatocellular carcinoma, reactive oxygen species, treatment, drug resistance, non-alcoholic fatty liver disease.
Abstract: Oxidative stress (OS) is a condition in which the body has an unbalanced oxidative and antioxidant
effect. Oxidative stress has emerged as a critical component in the onset and progression of
numerous diseases, including liver cancer and chronic liver disease caused by the hepatitis C virus and
hepatitis B virus. Reactive oxygen species (ROS) are the most prevalent reactive chemical species involved
in the oxidative stress response during the progression of the disease. Oxidative stress has a
unique role in the development of hepatocellular carcinoma (HCC), and excessive ROS production is a
common occurrence in liver illnesses of various etiologies. In response to various deleterious stimuli,
the liver shows manifestations of lipid accumulation, oxidative damage, inflammatory infiltration, and
immune response, which interact with each other in a mutually reinforcing manner, collectively exacerbating
liver damage and malignant transformation. The intracellular buildup of ROS is a two-edged
sword for tumor advancement. ROS are tumorigenic, and low amounts of ROS can trigger different
signaling pathways that promote proliferation, survival, and migration, among other aspects. However,
excessive oxidative stress can induce tumor cell death. Understanding the mechanisms of oxidative
stress in hepatocellular carcinogenesis is beneficial for the prevention and surveillance of hepatocellular
carcinoma in humans. An improved knowledge of the impacts and potential implications of oxidative
stress regulation in therapeutic strategies will likely allow us to find new therapeutic targets for
cancer. Oxidative stress also plays a significant role in the treatment of hepatocellular carcinoma and
the mechanisms of drug resistance involved. This paper reviews recent studies on oxidative stress in
HCC that are more reliable and important, and provides a more comprehensive view of the development
of the treatment of HCC based on the relevant summaries of the effect of oxidative stress on the
treatment.
