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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Hybrids Diazine: Recent Advancements in Modern Antimicrobial Therapy

Author(s): Violeta Mangalagiu, Ramona Danac, Dumitrela Diaconu*, Gheorghita Zbancioc and Ionel I. Mangalagiu*

Volume 31, Issue 19, 2024

Published on: 19 June, 2023

Page: [2687 - 2705] Pages: 19

DOI: 10.2174/0929867330666230418104409

Price: $65

Abstract

Nowadays, antimicrobial therapies have become a very challenging issue because of a large diversity of reasons such as antimicrobial resistance, over consumption and misuse of antimicrobial agents, etc. A modern, actual and very useful approach in antimicrobial therapy is represented by the use of hybrid drugs, especially combined five and six-membered ring azaheterocycles. In this review, we present an overview of the recent advanced data from the last five years in the field of hybrid diazine compounds with antimicrobial activity. In this respect, we highlight here essential data concerning the synthesis and antimicrobial activity of the main classes of diazine hybrids: pyridazine, pyrimidine, pyrazine, and their fused derivatives.

Keywords: Diazine hybrids, antimicrobial, pyridazine, pyrimidine, pyrazine, fused diazine.

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