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Current Traditional Medicine

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ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Review Article

Evidence and Prospects of Lycopene as Powerful Red Superfood: Modern Approach to Food Science

Author(s): Ena Gupta, Pragya Mishra, Priyanka Singh and Neha Mishra*

Volume 10, Issue 3, 2024

Published on: 25 May, 2023

Article ID: e170423215884 Pages: 11

DOI: 10.2174/2215083810666230417093938

Price: $65

Abstract

Lycopene is a plant-derived important nutrient belonging to a group of pigments identified as carotenoids. Lycopene has distinctive chemical and structural features contributing to definite biological properties. Lycopene is a powerful antioxidant and prevents cells and tissues from damage caused by singlet oxygen or free radicals. Research studies have shown the healthpromoting potential of lycopene or its metabolites in the prevention of chronic diseases like diabetes, cancer, asthma, metabolic syndrome, arthritis, and cardiovascular diseases. Lycopene is stable for processing like other natural compounds when present in the plant tissue matrix. Over the last few years, the global lycopene market has increased in different sectors like pharmaceuticals, cosmetics, food and dairy products, and other dietary supplements. The most important aspect of lycopene as a superfood is its synergistic nature with other nutrients. The main aim of this review article is to study chemistry, biosynthetic pathways, biotransformation, sources, and acceptable daily intake. Its characterization as a superfood, therapeutic potential, and wide range of applications in the food industry are also studied.

Keywords: Lycopene, cancer, therapeutic potential, superfood, food industry, arthritis.

Graphical Abstract
[1]
Nabi F, Arain MA, Rajput N, et al. Health benefits of carotenoids and potential application in poultry industry: A review. J Anim Physiol Anim Nutr 2020; 104(6): 1809-18.
[http://dx.doi.org/10.1111/jpn.13375] [PMID: 32333620]
[2]
Maoka T. Carotenoids as natural functional pigments. J Nat Med 2020; 74(1): 1-16.
[http://dx.doi.org/10.1007/s11418-019-01364-x] [PMID: 31588965]
[3]
Xianquan S, Shi J, Kakuda Y, Yueming J. Stability of lycopene during food processing and storage. J Med Food 2005; 8(4): 413-22.
[http://dx.doi.org/10.1089/jmf.2005.8.413] [PMID: 16379550]
[4]
Agarwal A, Shen H, Agarwal S, Rao AV. Lycopene content of tomato products: its stability, bioavailability and in vivo antioxidant properties. J Med Food 2001; 4(1): 9-15.
[http://dx.doi.org/10.1089/10966200152053668] [PMID: 12639283]
[5]
Przybylska S. Lycopene-a bioactive carotenoid offering multiple health benefits: A review. Int J Food Sci Technol 2020; 55(1): 11-32.
[http://dx.doi.org/10.1111/ijfs.14260]
[6]
Costa-Rodrigues J, Pinho O, Monteiro PRR. Can lycopene be considered an effective protection against cardiovascular disease? Food Chem 2018; 245: 1148-53.
[http://dx.doi.org/10.1016/j.foodchem.2017.11.055] [PMID: 29287334]
[7]
Pathak SS, Akhade OP, Bhojane KG, Sadar MD, Folane P, Biyani KR. A review on recent techniques of extraction and isolation of lycopene from tomato. Int J Res Rev 2020; 7: 487-90.
[8]
Wood LG, Garg ML, Powell H, Gibson PG. Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: Proof of concept. Free Radic Res 2008; 42(1): 94-102.
[http://dx.doi.org/10.1080/10715760701767307] [PMID: 18324527]
[9]
Chasse GA, Mak ML, Deretey E, et al. An ab initio computational study on selected lycopene isomers. J Mol Struct THEOCHEM 2001; 571(1-3): 27-37.
[http://dx.doi.org/10.1016/S0166-1280(01)00424-9]
[10]
Ruiz-Sola MÁ, Rodríguez-Concepción M. Carotenoid biosynthesis in Arabidopsis: A colorful pathway. Arabidopsis Book 2012; 10: e0158.
[http://dx.doi.org/10.1199/tab.0158] [PMID: 22582030]
[11]
Górecka D, Wawrzyniak A, Jędrusek-Golińska A, et al. Lycopene in tomatoes and tomato products. Open Chem 2020; 18(1): 752-6.
[http://dx.doi.org/10.1515/chem-2020-0050]
[12]
Kun Y, Ssonko Lule U, Xiao-Lin D. Lycopene: Its properties and relationship to human health. Food Rev Int 2006; 22(4): 309-33.
[http://dx.doi.org/10.1080/87559120600864753]
[13]
Bowen P, Chen L, Stacewicz-Sapuntzakis M, et al. Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp Biol Med 2002; 227(10): 886-93.
[http://dx.doi.org/10.1177/153537020222701008] [PMID: 12424330]
[14]
During A, Dawson HD, Harrison EH. Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr 2005; 135(10): 2305-12.
[http://dx.doi.org/10.1093/jn/135.10.2305] [PMID: 16177187]
[15]
Moussa M, Landrier JF, Reboul E, et al. Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1. J Nutr 2008; 138(8): 1432-6.
[http://dx.doi.org/10.1093/jn/138.8.1432] [PMID: 18641187]
[16]
Shi J, Maguer ML. Lycopene in tomatoes: chemical and physical properties affected by food processing. Crit Rev Food Sci Nutr 2000; 40(1): 1-42.
[http://dx.doi.org/10.1080/10408690091189275] [PMID: 10674200]
[17]
US Food supply database 2003. Available from: http://www.ars.usda.gov/ba/bhnrc/ndl
[18]
Story EN, Kopec RE, Schwartz SJ, Harris GK. An update on the health effects of tomato lycopene. Annu Rev Food Sci Technol 2010; 1(1): 189-210.
[http://dx.doi.org/10.1146/annurev.food.102308.124120] [PMID: 22129335]
[19]
Rao AV, Ali A. Biologically active phytochemicals in human health: Lycopene. Int J Food Prop 2007; 10(2): 279-88.
[http://dx.doi.org/10.1080/10942910601052673]
[20]
Trumbo PR. Are there adverse effects of lycopene exposure? J Nutr 2005; 135(8): S2060-1.
[http://dx.doi.org/10.1093/jn/135.8.2060S] [PMID: 16046742]
[21]
Porrini M, Riso P. What are typical lycopene intakes? J Nutr 2005; 135(8): S2042-5.
[http://dx.doi.org/10.1093/jn/135.8.2042S] [PMID: 16046736]
[22]
Mellert W, Deckardt K, Gembardt C, Schulte S, Ravenzwaay BV, Slesinski RS. Thirteen-week oral toxicity study of synthetic lycopene products in rats. Food Chem Toxicol 2002; 40(11): 1581-8.
[http://dx.doi.org/10.1016/S0278-6915(02)00113-8] [PMID: 12176084]
[23]
Bacanli M, Başaran N, Başaran AA. Lycopene: is it beneficial to human health as an antioxidant? Turkish Journal of Pharmaceutical Sciences 2017; 14(3): 311-8.
[http://dx.doi.org/10.4274/tjps.43043] [PMID: 32454630]
[24]
Alda LM, Gogoasa I, Bordean DM, et al. Lycopene content of tomatoes and tomato products. J Agroaliment Processes Technol 2009; 15(4): 540-2.
[25]
Benedictus L. The Truth about Superfoods. The Guardian 2016.
[26]
Riccioni G, Mancini B, Di Ilio E, Bucciarelli T, D’Orazio N. Protective effect of lycopene in cardiovascular disease. Eur Rev Med Pharmacol Sci 2008; 12(3): 183-90.
[PMID: 18700690]
[27]
Wolak T, Paran E. Can carotenoids attenuate vascular aging? Vascul Pharmacol 2013; 59(3-4): 63-6.
[http://dx.doi.org/10.1016/j.vph.2013.07.006] [PMID: 23906847]
[28]
Jacques PF, Lyass A, Massaro JM, Vasan RS, D’Agostino RB Sr. Relationship of lycopene intake and consumption of tomato products to incident CVD. Br J Nutr 2013; 110(3): 545-51.
[http://dx.doi.org/10.1017/S0007114512005417] [PMID: 23317928]
[29]
Jenab M, Ferrari P, Mazuir M, et al. Variations in lycopene blood levels and tomato consumption across European countries based on the European Prospective Investigation into Cancer and Nutrition (EPIC) study. J Nutr 2005; 135(8): S2032-6.
[http://dx.doi.org/10.1093/jn/135.8.2032S] [PMID: 16046733]
[30]
Friedman M. Anticarcinogenic, cardioprotective, and other health benefits of tomato compounds lycopene, α-tomatine, and tomatidine in pure form and in fresh and processed tomatoes. J Agric Food Chem 2013; 61(40): 9534-50.
[http://dx.doi.org/10.1021/jf402654e] [PMID: 24079774]
[31]
Shen YC, Chen SL, Wang CK. Contribution of tomato phenolics to antioxidation and down-regulation of blood lipids. J Agric Food Chem 2007; 55(16): 6475-81.
[http://dx.doi.org/10.1021/jf070799z] [PMID: 17629300]
[32]
Bose KS, Agrawal BK. Effect of lycopene from cooked tomatoes on serum antioxidant enzymes, lipid peroxidation rate and lipid profile in coronary heart disease. Singapore Med J 2007; 48(5): 415-20.
[PMID: 17453080]
[33]
Paran E, Engelhard Y. Effect of tomato’s lycopene on blood pressure, serum lipoproteins, plasma homocysteine and oxidative sress markers in grade I hypertensive patients. Am J Hypertens 2001; 14(11): A141.
[http://dx.doi.org/10.1016/S0895-7061(01)01854-4]
[34]
Khan UM, Sevindik M, Zarrabi A, et al. Lycopene: Food sources, biological activities, and human health benefits. Oxid Med Cell Longev 2021; 2021: 1-10.
[http://dx.doi.org/10.1155/2021/2713511] [PMID: 34840666]
[35]
Rissanen TH, Voutilainen S, Nyyssönen K, et al. Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr 2001; 85(6): 749-54.
[http://dx.doi.org/10.1079/BJN2001357] [PMID: 11430780]
[36]
Coyne T, Ibiebele TI, Baade PD, et al. Diabetes mellitus and serum carotenoids: findings of a population-based study in Queensland, Australia. Am J Clin Nutr 2005; 82(3): 685-93.
[http://dx.doi.org/10.1093/ajcn/82.3.685] [PMID: 16155284]
[37]
Riso P, Visioli F, Grande S, et al. Effect of a tomato-based drink on markers of inflammation, immunomodulation, and oxidative stress. J Agric Food Chem 2006; 54(7): 2563-6.
[http://dx.doi.org/10.1021/jf053033c] [PMID: 16569044]
[38]
Duzguner V, Kucukgul A, Erdogan S, Celik S, Sahin K. Effect of lycopene administration on plasma glucose, oxidative stress and body weight in streptozotocin diabetic rats. J Appl Anim Res 2008; 33(1): 17-20.
[http://dx.doi.org/10.1080/09712119.2008.9706888]
[39]
Salman H, Bergman M, Djaldetti M, Bessler H. Lycopene affects proliferation and apoptosis of four malignant cell lines. Biomed Pharmacother 2007; 61(6): 366-9.
[http://dx.doi.org/10.1016/j.biopha.2007.02.015] [PMID: 17448625]
[40]
Sesso HD, Buring JE, Zhang SM, Norkus EP, Gaziano JM. Dietary and plasma lycopene and the risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2005; 14(5): 1074-81.
[http://dx.doi.org/10.1158/1055-9965.EPI-04-0683] [PMID: 15894655]
[41]
Nahum A, Hirsch K, Danilenko M, et al. Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27Kip1 in the cyclin E–cdk2 complexes. Oncogene 2001; 20(26): 3428-36.
[http://dx.doi.org/10.1038/sj.onc.1204452] [PMID: 11423993]
[42]
Liu D, Shi J, Colina Ibarra A, Kakuda Y, Jun Xue S. The scavenging capacity and synergistic effects of lycopene, vitamin E, vitamin C, and β-carotene mixtures on the DPPH free radical. Lebensm Wiss Technol 2008; 41(7): 1344-9.
[http://dx.doi.org/10.1016/j.lwt.2007.08.001]
[43]
Liu F, Zhang ZZ, Wu M, Shu Y. Study on the protective effect of tomato juice on DNA damage in cells. Sichuan Da Xue Xue Bao Yi Xue Ban 2007; 38(1): 18-21.
[PMID: 17294719]
[44]
Scolastici C, Alves de Lima RO, Barbisan LF, Ferreira ALA, Ribeiro DA, Salvadori DMF. Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and micronucleus test. Toxicol In Vitro 2008; 22(2): 510-4.
[http://dx.doi.org/10.1016/j.tiv.2007.11.002] [PMID: 18077131]
[45]
Matlaga BR, Hall MC, Stindt D, Torti FM. Response of hormone refractory prostate cancer to lycopene. The Journal of urology 2001; 166(2): 613.
[http://dx.doi.org/10.1016/S0022-5347(05)66000-4]
[46]
Hwang ES, Lee HJ. Inhibitory effects of lycopene on the adhesion, invasion, and migration of SK-Hep1 human hepatoma cells. Exp Biol Med 2006; 231(3): 322-7.
[http://dx.doi.org/10.1177/153537020623100313] [PMID: 16514180]
[47]
Holzapfel N, Holzapfel B, Champ S, Feldthusen J, Clements J, Hutmacher D. The potential role of lycopene for the prevention and therapy of prostate cancer: from molecular mechanisms to clinical evidence. Int J Mol Sci 2013; 14(7): 14620-46.
[http://dx.doi.org/10.3390/ijms140714620] [PMID: 23857058]
[48]
Rao LG, Krishnadev N, Banasikowska K, Rao AV. Lycopene I--effect on osteoclasts: lycopene inhibits basal and parathyroid hormone-stimulated osteoclast formation and mineral resorption mediated by reactive oxygen species in rat bone marrow cultures. J Med Food 2003; 6(2): 69-78.
[http://dx.doi.org/10.1089/109662003322233459] [PMID: 12935316]
[49]
Kim L, Rao AV, Rao LG. Lycopene II--effect on osteoblasts: the carotenoid lycopene stimulates cell proliferation and alkaline phosphatase activity of SaOS-2 cells. J Med Food 2003; 6(2): 79-86.
[http://dx.doi.org/10.1089/109662003322233468] [PMID: 12935317]
[50]
Russo C, Ferro Y, Maurotti S, et al. Lycopene and bone: An in vitro investigation and a pilot prospective clinical study. J Transl Med 2020; 18(1): 43.
[http://dx.doi.org/10.1186/s12967-020-02238-7] [PMID: 31996227]
[51]
Ardawi MSM, Badawoud MH, Hassan SM, et al. Lycopene treatment against loss of bone mass, microarchitecture and strength in relation to regulatory mechanisms in a postmenopausal osteoporosis model. Bone 2016; 83: 127-40.
[http://dx.doi.org/10.1016/j.bone.2015.10.017] [PMID: 26549245]
[52]
Mackinnon ES, Rao AV, Josse RG, Rao LG. Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women. Osteoporos Int 2011; 22(4): 1091-101.
[http://dx.doi.org/10.1007/s00198-010-1308-0] [PMID: 20552330]
[53]
Qu M, Li L, Chen C, et al. Protective effects of lycopene against amyloid β-induced neurotoxicity in cultured rat cortical neurons. Neurosci Lett 2011; 505(3): 286-90.
[http://dx.doi.org/10.1016/j.neulet.2011.10.048] [PMID: 22044877]
[54]
Qu M, Zhou Z, Chen C, et al. Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway. Neurochem Int 2011; 59(8): 1095-103.
[http://dx.doi.org/10.1016/j.neuint.2011.10.005] [PMID: 22032970]
[55]
Akbaraly NT, Faure H, Gourlet V, Favier A, Berr C. Plasma carotenoid levels and cognitive performance in an elderly population: results of the EVA Study. J Gerontol A Biol Sci Med Sci 2007; 62(3): 308-16.
[http://dx.doi.org/10.1093/gerona/62.3.308] [PMID: 17389729]
[56]
Hwang S, Lim J, Kim H. Inhibitory effect of lycopene on amyloid-β-induced apoptosis in neuronal cells. Nutrients 2017; 9(8): 883.
[http://dx.doi.org/10.3390/nu9080883] [PMID: 28813012]
[57]
Adewoyin M, Ibrahim M, Roszaman R, et al. Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress. Diseases 2017; 5(1): 9.
[http://dx.doi.org/10.3390/diseases5010009] [PMID: 28933362]
[58]
Mohanty NK, Kumar S, Jha AK, Arora RP. Management of idiopathic oligoasthenospermia with lycopene. Indian J Urol 2001; 18(1): 57.
[59]
Oborna I, Malickova K, Fingerova H, et al. A randomized controlled trial of lycopene treatment on soluble receptor for advanced glycation end products in seminal and blood plasma of normospermic men. Am J Reprod Immunol 2011; 66(3): 179-84.
[http://dx.doi.org/10.1111/j.1600-0897.2011.00984.x] [PMID: 21276122]
[60]
Choi SK, Seo JS. Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils. Nutr Res Pract 2013; 7(1): 26-33.
[http://dx.doi.org/10.4162/nrp.2013.7.1.26] [PMID: 23423845]
[61]
Gupta SK, Trivedi D, Srivastava S, Joshi S, Halder N, Verma SD. Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study. Nutrition 2003; 19(9): 794-9.
[http://dx.doi.org/10.1016/S0899-9007(03)00140-0] [PMID: 12921892]
[62]
Kumar P, Kumar A. Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: A novel nitric oxide mechanism. Food Chem Toxicol 2009; 47(10): 2522-30.
[http://dx.doi.org/10.1016/j.fct.2009.07.011] [PMID: 19616597]
[63]
De Pablo P, Dietrich T, Karlson EW. Antioxidants and other novel cardiovascular risk factors in subjects with rheumatoid arthritis in a large population sample. Arthritis Rheum 2007; 57(6): 953-62.
[http://dx.doi.org/10.1002/art.22912] [PMID: 17665477]
[64]
Riccioni G, Bucciarelli T, Mancini B, Ilio CD, Vecchia RD, D’Orazio N. Plasma lycopene and antioxidant vitamins in asthma: the PLAVA study. J Asthma 2007; 44(6): 429-32.
[http://dx.doi.org/10.1080/02770900701421880] [PMID: 17654127]
[65]
Domínguez R, Gullón P, Pateiro M, Munekata PES, Zhang W, Lorenzo JM. Tomato as potential source of natural additives for meat industry. A review. Antioxidants 2020; 9(1): 73.
[http://dx.doi.org/10.3390/antiox9010073] [PMID: 31952111]
[66]
Østerlie M, Lerfall J. Lycopene from tomato products added minced meat: Effect on storage quality and colour. Food Res Int 2005; 38(8-9): 925-9.
[http://dx.doi.org/10.1016/j.foodres.2004.12.003]
[67]
Jiang H, Wang Z, Ma Y, et al. Effect of dietary lycopene supplementation on growth performance, meat quality, fatty acid profile and meat lipid oxidation in lambs in summer conditions. Small Rumin Res 2015; 131: 99-106.
[http://dx.doi.org/10.1016/j.smallrumres.2015.08.017]
[68]
Bhat NA, Wani IA, Hamdani AM. Tomato powder and crude lycopene as a source of natural antioxidants in whole wheat flour cookies. Heliyon 2020; 6(1): e03042.
[http://dx.doi.org/10.1016/j.heliyon.2019.e03042] [PMID: 31989047]
[69]
Wirivutthikorn W. Optimum ratios of okra and tangerine on production of mixed juice with lycopene supplementation. Int J GEOMATE 2019; 17(61): 8-13.
[http://dx.doi.org/10.21660/2019.61.4503]
[70]
Luo H, Bao Y, Zhu P. Development of a novel functional yogurt rich in lycopene by Bacillus subtilis. Food Chem 2023; 407135142
[http://dx.doi.org/10.1016/j.foodchem.2022.135142] [PMID: 36493487]
[71]
Olempska-Beer Z. Lycopenes (Synthetic) Chemical and Technical Assessment. 2006. Available from: ftp://ftp. org/ag/agn/jecfa/cat_lycopene. pdf
[72]
Alimentarius C. Guidelines for the Production, Processing, Labelling and Marketing of Organically Produced Foods. GL 32-1999. Adopted 1999. Revisions 2001, 2003, 2004 and 2007. Amendments 2008, 2009, 2010 and 2012 (2001, rev. 2012)

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