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Perspective

富替替尼:一种治疗胆管癌的有效且不可逆的成纤维细胞生长因子受体抑制剂

卷 31, 期 6, 2024

发表于: 24 May, 2023

页: [666 - 670] 页: 5

弟呕挨: 10.2174/0929867330666230416152913

摘要

胆管癌是一种罕见的癌症。福替替尼是一种不可逆的、有效的、选择性的成纤维细胞生长因子受体(FGFR 1-4)抑制剂。2022年9月30日，美国FDA首次批准福替替尼用于治疗不可切除、局部晚期或转移性肝内胆管癌患者，这些患者存在成纤维细胞生长因子受体2 (FGFR2)基因突变或其他类型的重排。该药的批准是基于3期临床试验结果，包括42%的总缓解率(ORR)和9.7个月的反应持续时间(DoR)。本文简要介绍了福替替尼的合成、理化性质、剂量、给药途径、作用机制、结合方式、药效学、药代动力学、药物相互作用、不良事件以及可能的耐药机制。

关键词: 胆管癌，福替替尼，成纤维细胞生长因子受体，药效学，药代动力学，药物相互作用。

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