Title:An Investigation into the Effects of Chemical, Pharmaceutical, and
Herbal Compounds on Neuroglobin: A Literature Review
Volume: 31
Issue: 20
关键词:
医药、草药、化合物、营养、神经球蛋白(Ngb)、铁螯合剂。
摘要: Neuroglobin (Ngb) is an oxygen-binding globin protein that is mainly expressed
in the neurons of the central and peripheral nervous system. However, moderate
levels of Ngb have also been detected in non-neural tissues. Ngb and Ngb modulating factors
have been increasingly studied over the last decade due to their neuroprotective role
in neurological disorders and hypoxia. Studies have shown that a number of chemicals,
pharmaceuticals, and herbal compounds can modulate the expression of Ngb at different
dose levels, indicating a protective role against neurodegenerative diseases. Iron chelators,
hormones, antidiabetic drugs, anticoagulants, antidepressants, plant derivatives and
short-chain fatty acids are among these compounds. Therefore, this study aimed to review
the literature focused on the possible effects and mechanisms of chemical, pharmaceutical,
and herbal compounds on Ngbs.