Title:Immunological Facet and Inception after Post-COVID-19 Vaccination
Volume: 23
Issue: 5
Author(s): Suman Kumar Ray and Sukhes Mukherjee*
Affiliation:
- Department of Biochemistry, All India Institute of
Medical Sciences, Bhopal, Madhya Pradesh, 462020, India
Keywords:
COVID-19, SARS-CoV-2 infection, vaccination, autoimmune phenomenon, immunological inception, Long COVID Syndrome.
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced coronavirus disease
2019 (COVID-19) pandemic has produced an unparalleled setback for the world's economy and
health. One of the best therapies to significantly lower severe illness and mortality from SARS-CoV-2
infection is vaccination. Worldwide vaccination campaigns are being implemented. New-onset autoimmune
problems, such as immune thrombotic thrombocytopenia, autoimmune liver disorders, IgA
nephropathy, Guillain-Barré syndrome, systemic lupus erythematosus, and rheumatoid arthritis, have
recently been described more frequently after receiving COVID-19 vaccine. The creation of specific
autoantibodies, molecular mimicry, and the function of specific vaccine adjuvants all emerge to play a
significant role in autoimmunity. The post-acute sequelae of SARS-CoV-2, usually known as Long
Covid Syndrome, are beginning to be better understood in terms of the disparities in immune responses
seen in individuals with and without the condition. We anticipate that the knowledge gleaned from
several COVID-19 investigations will be put to use in research on the inflammatory mechanisms implicated
in serious and protracted illnesses, which is still a key unmet need.
