Title:Chemical Detoxification of Therapeutic Hybrid Complexes Prepared by the
Compatible Combination of Ayurvedic Herb and Allopathic Drug
Volume: 1
Author(s): Mishra Bhawana, Pant Deepak*, Gothwal Suraj, Garhwal Akash, Yadav Sanjay Ramnarayan and Nadda Kumar Ashok
Affiliation:
- Department of Environmental Science, Central University of Himachal Pradesh (CUHP), Dharamshala, Shahpur, Himachal Pradesh, 176206, India
Keywords:
Integration, Hybrid Drug, Ayurveda, Allopathy, Antacids drug, Antibacterial Drug, Antiviral drug.
Abstract:
Background & Objective:
The treatment of diseases and good health maintenance are the common fundamental aims of ayurvedic and allopathic medical systems. Limited
information is available in the public domain for the concept of symbiohealth, i.e., the symbiotic interaction of ayurveda and allopathy, that needs
to be explored for an efficient and robust health system. Therefore, an attempt has been made to reduce the toxicity of therapeutic drugs via the
integration approach of ayurveda and allopathy.
Methods:
Three different categories of allopathy and ayurvedic medicines, such as antacids (omeprazole, ranitidine, and sooktybhasma), antibacterial
(amoxicillin trihydrate, ciprofloxacin hydrochloride, Curcuma longa, and Datura stramonium) and antiviral (acyclovir, efavirenz, Echinacea,
Calendula, Allium sativum, and Citrullus colocynthis) were targeted.
Results:
Best therapeutic hybrid combination was obtained on the basis of their UV absorption maxima and peak shift. Acyclovir with A. sativum (1-6%),
sooktybhasma 20% with rantidine, Ciprofloxacin HCl (2%) with 10% aqueous datura and Ciprofloxacin HCl (0.02-0.2%) with 0.02-0.06%
acetonitrile turmeric showed best integration result. This drug integration can be applied to improve the potential results or detoxification of hybrid
drugs that target the drug moiety results in reduced side effects or the dose of important drugs, which might be due to the chelation pattern of their
functional group, absorption, bonding, and pi-pi interaction.
Conclusion:
This study will provide the leadership for the betterment of a therapeutic hybrid drug complex that might be useful as an allopathic drug and less
harmful than its ayurvedic component. The proposed integration fusion of different medication therapies, such as Ayurvedic and allopathic, has the
potential for a scientific merger.
