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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Mini-Review Article

Plants of the Genus Mahonia as a Potential Traditional Chinese Medicine for the Prevention and Treatment of Alzheimer's Disease

Author(s): Shuo Yang, Huikai Shao, Xiyu Chen, Qiwen Liu, Shengfeng Huang* and Yang Huang*

Volume 23, Issue 13, 2023

Published on: 28 April, 2023

Page: [1214 - 1220] Pages: 7

DOI: 10.2174/1568026623666230330105251

Price: $65

Abstract

Alzheimer’s disease (AD), a prevalent multiple neurodegenerative disease, has gained attention, particularly in the aging population. However, presently available therapies merely focus on alleviating the symptoms of AD and fail to slow disease progression significantly. Traditional Chinese medicine (TCM) has been used to ameliorate symptoms or interfere with the pathogenesis of aging-associated diseases for many years based on disease-modifying in multiple pathological roles with multi-targets, multi-systems and multi-aspects. Mahonia species as a TCM present potential for anti-inflammatory activity, antioxidant activity, anti-acetylcholinesterase activity, and antiamyloid- beta activity that was briefly discussed in this review. They are regarded as promising drug candidates for AD therapy. The findings in this review support the use of Mahonia species as an alternative therapy source for treating AD.

Keywords: Mahonia species, traditional Chinese medicine, Alzheimer's disease, Anti-inflammatory activity, antioxidant activities, anti-acetylcholinesterase activity.

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