Title:Serine Protease 27, a Prognostic Biomarker in Pan-cancer and
Associated with the Aggressive Progression of Breast Cancer
Volume: 31
Issue: 15
Author(s): Yiying Xu, Yanyan Shen, Adheesh Bhandari, Suzita Hirachan, Ouchen Wang*Erjie Xia*
Affiliation:
- Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang,
325000, PR China
- Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang,
325000, PR China
Keywords:
PRSS27, pan-cancer, breast cancer, prognostic, IL-17 signaling pathway, oncogenic processes.
Abstract:
Background: To create effective medicines, researchers must first identify the
common or unique genes that drive oncogenic processes in human cancers. Serine protease
27 (PRSS27) has been recently defined as a possible driver gene in esophageal squamous
cell carcinoma. However, no thorough pan-cancer study has been performed to
date, including breast cancer.
Methods: Using the TCGA (The Cancer Genome Atlas), the GEO (Gene Expression Omnibus)
dataset, and multiple bioinformatic tools, we investigated the function of PRSS27
in 33 tumor types. In addition, prognosis analysis of PRSS27 in breast cancer was carried
out, as well as in vitro experiments to verify its role as an oncogene. We first explored
the expression of PRSS27 in over 10 tumors and then we looked into PRSS27 genomic
mutations.
Results: We discovered that PRSS27 has prognostic significance in breast cancer and
other cancers' survival, and we developed a breast cancer prognostic prediction model by
combining a defined set of clinical factors. Besides, we confirmed PRSS27 as an oncogene
in breast cancer using some primary in vitro experiments.
Conclusion: Our pan-cancer survey has comprehensively reviewed the oncogenic function
of PRSS27 in various human malignancies, suggesting that it may be a promising
prognostic biomarker and tumor therapeutic target in breast cancer.
