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Review Article

全球公共卫生中对缺铁作为人类疾病原因的看法

卷 31, 期 12, 2024

发表于: 15 May, 2023

页: [1428 - 1440] 页: 13

弟呕挨: 10.2174/0929867330666230324154606

价格: $65

摘要

铁 (Fe) 是人体新陈代谢众多途径中必需的微量元素。 因此，缺铁会导致多种健康问题。 除了众所周知的小细胞性贫血外，缺乏铁还会导致儿童、孕妇和成人严重的精神运动障碍。 缺铁是一个全球性的健康问题，主要是由饮食缺乏引起的，但炎症状况会加剧缺铁。 需要在国家和国际层面解决与这一缺陷相关的挑战。 本综述旨在简要总结全球公共卫生背景下缺铁造成的疾病负担，并希望提供一些实践指南。

关键词: 铁、公共卫生、全球健康、缺铁、铁强化、儿童、孕妇。

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[1]
Anderson, G.J.; Frazer, D.M. Current understanding of iron homeostasis. Am. J. Clin. Nutr., 2017, 106(Suppl. 6), 1559S-1566S.
[http://dx.doi.org/10.3945/ajcn.117.155804] [PMID: 29070551]
[2]
Chaparro, C.M.; Suchdev, P.S. Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. Ann. N. Y. Acad. Sci., 2019, 1450(1), nyas.14092.
[http://dx.doi.org/10.1111/nyas.14092] [PMID: 31008520]
[3]
Mattiello, V.; Schmugge, M.; Hengartner, H.; von der Weid, N.; Renella, R. Diagnosis and management of iron deficiency in children with or without anemia: consensus recommendations of the SPOG Pediatric Hematology Working Group. Eur. J. Pediatr., 2020, 179(4), 527-545.
[http://dx.doi.org/10.1007/s00431-020-03597-5] [PMID: 32020331]
[4]
Badireddy, M.; Baradhi, K.M. Chronic Anemia; In StatPearls: Treasure Island, FL, 2022.
[5]
Shah, Y.M.; Matsubara, T.; Ito, S.; Yim, S.H.; Gonzalez, F.J. Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab., 2009, 9(2), 152-164.
[http://dx.doi.org/10.1016/j.cmet.2008.12.012] [PMID: 19147412]
[6]
Lewis, S.M.; Emmanuel, J.C. Iron Deficiency and Overload: From basic biology to clinical medicine; Yehuda, S.; Mostofsky, D.I., Eds.; Humana Press: Totowa, NJ, 2010, pp. 299-312.
[http://dx.doi.org/10.1007/978-1-59745-462-9_17]
[7]
Ogun, A.S.; Adeyinka, A. Biochemistry, Transferrin; In StatPearls: Treasure Island, FL, 2022.
[8]
Zoroddu, M.A.; Aaseth, J.; Crisponi, G.; Medici, S.; Peana, M.; Nurchi, V.M. The essential metals for humans: a brief overview. J. Inorg. Biochem., 2019, 195, 120-129.
[http://dx.doi.org/10.1016/j.jinorgbio.2019.03.013] [PMID: 30939379]
[9]
Gropper, S.; Smith, J.; Groff, J. Advanced nutrition and human metabolism, 6th ed.; Wardsworth Cengage Learning: Belmont, CA, 2013.
[10]
Imam, H.S.H.; Anwar, M.I.; Anwar, M.F.; Murtaza, M.; Sadiq, R. Role of iron supplements on pregnancy outcomes. Ann. Punjab Med. Coll., 2017, 11(4), 320-324.
[http://dx.doi.org/10.29054/APMC/17.442]
[11]
Domellöf, M.; Braegger, C.; Campoy, C.; Colomb, V.; Decsi, T.; Fewtrell, M.; Hojsak, I.; Mihatsch, W.; Molgaard, C.; Shamir, R.; Turck, D.; van Goudoever, J. Iron requirements of infants and toddlers. J. Pediatr. Gastroenterol. Nutr., 2014, 58(1), 119-129.
[http://dx.doi.org/10.1097/MPG.0000000000000206] [PMID: 24135983]
[12]
Naoum, F.A. Iron deficiency in cancer patients. Rev. Bras. Hematol. Hemoter., 2016, 38(4), 325-330.
[http://dx.doi.org/10.1016/j.bjhh.2016.05.009] [PMID: 27863761]
[13]
Rodgers, G.M., III; Becker, P.S.; Blinder, M.; Cella, D.; Chanan-Khan, A.; Cleeland, C.; Coccia, P.F.; Djulbegovic, B.; Gilreath, J.A.; Kraut, E.H.; Matulonis, U.A.; Millenson, M.M.; Reinke, D.; Rosenthal, J.; Schwartz, R.N.; Soff, G.; Stein, R.S.; Vlahovic, G.; Weir, A.B., III Cancer- and chemotherapy-induced anemia. J. Natl. Compr. Canc. Netw., 2012, 10(5), 628-653.
[http://dx.doi.org/10.6004/jnccn.2012.0064] [PMID: 22570293]
[14]
Gelaw, Y.; Getaneh, Z.; Melku, M. Anemia as a risk factor for tuberculosis: a systematic review and meta-analysis. Environ. Health Prev. Med., 2021, 26(1), 13.
[http://dx.doi.org/10.1186/s12199-020-00931-z] [PMID: 33485299]
[15]
Nairz, M.; Weiss, G. Iron in infection and immunity. Mol. Aspects Med., 2020, 75, 100864.
[http://dx.doi.org/10.1016/j.mam.2020.100864] [PMID: 32461004]
[16]
Cohen-Solal, A.; Damy, T.; Terbah, M.; Kerebel, S.; Baguet, J.P.; Hanon, O.; Zannad, F.; Laperche, T.; Leclercq, C.; Concas, V.; Duvillié, L.; Darné, B.; Anker, S.; Mebazaa, A. High prevalence of iron deficiency in patients with acute decompensated heart failure. Eur. J. Heart Fail., 2014, 16(9), 984-991.
[http://dx.doi.org/10.1002/ejhf.139] [PMID: 25065368]
[17]
Yancy, C.W.; Jessup, M.; Bozkurt, B.; Butler, J.; Casey, D.E., Jr; Colvin, M.M.; Drazner, M.H.; Filippatos, G.S.; Fonarow, G.C.; Givertz, M.M.; Hollenberg, S.M.; Lindenfeld, J.; Masoudi, F.A.; McBride, P.E.; Peterson, P.N.; Stevenson, L.W.; Westlake, C. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure. J. Am. Coll. Cardiol., 2017, 70(6), 776-803.
[http://dx.doi.org/10.1016/j.jacc.2017.04.025] [PMID: 28461007]
[18]
Batchelor, E.K.; Kapitsinou, P.; Pergola, P.E.; Kovesdy, C.P.; Jalal, D.I. Iron deficiency in chronic kidney disease: updates on pathophysiology, diagnosis, and treatment. J. Am. Soc. Nephrol., 2020, 31(3), 456-468.
[http://dx.doi.org/10.1681/ASN.2019020213] [PMID: 32041774]
[19]
Pasricha, S.R.; Tye-Din, J.; Muckenthaler, M.U.; Swinkels, D.W. Iron deficiency. Lancet, 2021, 397(10270), 233-248.
[http://dx.doi.org/10.1016/S0140-6736(20)32594-0] [PMID: 33285139]
[20]
Abboud, S.; Haile, D.J. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J. Biol. Chem., 2000, 275(26), 19906-19912.
[http://dx.doi.org/10.1074/jbc.M000713200]
[21]
Wallace, D.F. The regulation of iron absorption and homeostasis. Clin. Biochem. Rev, 2016, 37(2), 51-62.
[22]
Ems, T.; St Lucia, K.; Huecker. Dietary Iron; In StatPearls: Treasure Island, FL, 2022.
[23]
Ito, H.; Kurokawa, H.; Matsui, H. Mitochondrial reactive oxygen species and heme, non-heme iron metabolism. Arch. Biochem. Biophys., 2021, 700, 108695.
[http://dx.doi.org/10.1016/j.abb.2020.108695] [PMID: 33232715]
[24]
Feizollahi, E.; Mirmahdi, R.S.; Zoghi, A.; Zijlstra, R.T.; Roopesh, M.S.; Vasanthan, T. Review of the beneficial and anti-nutritional qualities of phytic acid, and procedures for removing it from food products. Food Res. Int., 2021, 143, 110284.
[http://dx.doi.org/10.1016/j.foodres.2021.110284] [PMID: 33992384]
[25]
Porter, J.L.; Rawla, P. Hemochromatosis; In StatPearls: Treasure Island, FL, 2022.
[26]
Lang, F.; Qadri, S.M. Mechanisms and significance of eryptosis, the suicidal death of erythrocytes. Blood Purif., 2012, 33(1-3), 125-130.
[http://dx.doi.org/10.1159/000334163] [PMID: 22269222]
[27]
Abbasi, U.; Abbina, S.; Gill, A.; Takuechi, L.E.; Kizhakkedathu, J.N. Role of iron in the molecular pathogenesis of diseases and therapeutic opportunities. ACS Chem. Biol., 2021, 16(6), 945-972.
[http://dx.doi.org/10.1021/acschembio.1c00122] [PMID: 34102834]
[28]
Liu, Q.; Wu, J.; Zhang, X.; Wu, X.; Zhao, Y.; Ren, J. Iron homeostasis and disorders revisited in the sepsis. Free Radic. Biol. Med., 2021, 165, 1-13.
[http://dx.doi.org/10.1016/j.freeradbiomed.2021.01.025] [PMID: 33486088]
[29]
Buck, E.; Finnigan, N.A. Malaria; In StatPearls: Treasure Island, FL, 2022.
[30]
Galaris, D.; Barbouti, A.; Pantopoulos, K. Iron homeostasis and oxidative stress: An intimate relationship. Biochim. Biophys. Acta Mol. Cell Res., 2019, 1866(12), 118535.
[http://dx.doi.org/10.1016/j.bbamcr.2019.118535] [PMID: 31446062]
[31]
Imam, M.; Zhang, S.; Ma, J.; Wang, H.; Wang, F. Antioxidants mediate both iron homeostasis and oxidative stress. Nutrients, 2017, 9(7), 671.
[http://dx.doi.org/10.3390/nu9070671] [PMID: 28657578]
[32]
Warner, M.J.; Kamran, M.T. Iron Deficiency Anemia; In StatPearls: Treasure Island, FL, 2022.
[33]
Institute of Medicine (US) Committee on Micronutrient Deficiencies In: Prevention of Micronutrient Deficiencies: Tools for Policymakers and Public Health Workers; Howson, C.P.; Kennedy, E.T.; Horwitz, A., Eds.; Washington (DC), 1998.
[http://dx.doi.org/10.17226/5962]
[34]
Ghodeif, A.O.; Jain, H. Hookworm; StatPearls: Treasure Island (FL), 2022.
[35]
Salam, R.A.; Das, J.K.; Bhutta, Z.A. Effect of mass deworming with antihelminthics for soil-transmitted helminths during pregnancy. Cochrane Libr., 2021, 2021(5), CD005547.
[http://dx.doi.org/10.1002/14651858.CD005547.pub4] [PMID: 33998661]
[36]
DeVos, E.; Dunn, N. Malaria Prophylaxis; In StatPearls: Treasure Island, FL, 2022.
[37]
Gahagan, S.; Delker, E.; Blanco, E.; Burrows, R.; Lozoff, B. Randomized controlled trial of iron-fortified versus low-iron infant formula: developmental outcomes at 16 years. J. Pediatr., 2019, 212, 124-130.e1.
[http://dx.doi.org/10.1016/j.jpeds.2019.05.030] [PMID: 31253407]
[38]
Rose, E. Pediatric fever. Emerg. Med. Clin. North Am., 2021, 39(3), 627-639.
[http://dx.doi.org/10.1016/j.emc.2021.04.011] [PMID: 34215406]
[39]
Turner, J.; Parsi, M.; Badireddy, M. Normochromic Normocytic Anemia; In StatPearls: Treasure Island, FL, 2022.
[40]
Petry, N.; Olofin, I.; Hurrell, R.; Boy, E.; Wirth, J.; Moursi, M.; Donahue Angel, M.; Rohner, F. The proportion of anemia associated with iron deficiency in low, medium, and high human development index countries: A systematic analysis of national surveys. Nutrients, 2016, 8(11), 693.
[http://dx.doi.org/10.3390/nu8110693] [PMID: 27827838]
[41]
Omena, J.; Curioni, C.; Cople-Rodrigues, C.S.; Citelli, M. The effect of food and nutrients on iron overload: what do we know so far? Eur. J. Clin. Nutr., 2021, 75(12), 1771-1780.
[http://dx.doi.org/10.1038/s41430-021-00887-5] [PMID: 33712721]
[42]
Ojukwu, J.U.; Okebe, J.U.; Yahav, D.; Paul, M. Oral iron supplementation for preventing or treating anaemia among children in malaria-endemic areas. Cochrane Database Syst. Rev., 2009, (3), CD006589.
[http://dx.doi.org/10.1002/14651858.CD006589.pub2] [PMID: 19588399]
[43]
Okebe, J.U.; Yahav, D.; Shbita, R.; Paul, M. Oral iron supplements for children in malaria-endemic areas. Cochrane Database Syst. Rev., 2011, (10), CD006589.
[http://dx.doi.org/10.1002/14651858.CD006589.pub3] [PMID: 21975754]
[44]
Neuberger, A.; Okebe, J.; Yahav, D.; Paul, M. Oral iron supplements for children in malaria-endemic areas. Cochrane Libr., 2016, 2016(2), CD006589.
[http://dx.doi.org/10.1002/14651858.CD006589.pub4] [PMID: 26921618]
[45]
Cantor, A.G.; Bougatsos, C.; Dana, T.; Blazina, I.; McDonagh, M. Routine iron supplementation and screening for iron deficiency anemia in pregnancy: a systematic review for the U.S. Preventive Services Task Force. Ann. Intern. Med., 2015, 162(8), 566-576.
[http://dx.doi.org/10.7326/M14-2932]
[46]
Pasricha, S.R; Drakesmith, H.; Black, J.; Hipgrave, D.; Biggs, B.A. Control of iron deficiency anemia in low- and middle-income countries. Blood, 2013, 121(14), 2607-2617.
[47]
Muthayya, S.; Rah, J.H.; Sugimoto, J.D.; Roos, F.F.; Kraemer, K.; Black, R.E. The global hidden hunger indices and maps: an advocacy tool for action. PLoS One, 2013, 8(6), e67860.
[http://dx.doi.org/10.1371/journal.pone.0067860] [PMID: 23776712]
[48]
Sachdev, H.P.S.; Gera, T. Preventing childhood anemia in India: iron supplementation and beyond. Eur. J. Clin. Nutr., 2013, 67(5), 475-480.
[http://dx.doi.org/10.1038/ejcn.2012.212] [PMID: 23388662]
[49]
Swaminathan, S.; Edward, B.S.; Kurpad, A.V. Micronutrient deficiency and cognitive and physical performance in Indian children. Eur. J. Clin. Nutr., 2013, 67(5), 467-474.
[http://dx.doi.org/10.1038/ejcn.2013.14] [PMID: 23403875]
[50]
Beard, J.L. Why iron deficiency is important in infant development. J. Nutr., 2008, 138(12), 2534-2536.
[http://dx.doi.org/10.1093/jn/138.12.2534] [PMID: 19022985]
[51]
Peirano, P.D.; Algarín, C.R.; Chamorro, R.; Reyes, S.; Garrido, M.I.; Duran, S.; Lozoff, B. Sleep and neurofunctions throughout child development: lasting effects of early iron deficiency. J. Pediatr. Gastroenterol. Nutr., 2009, 48(Suppl. 1), S8-S15.
[http://dx.doi.org/10.1097/MPG.0b013e31819773b] [PMID: 19214058]
[52]
Youdim, M.B.H. Brain iron deficiency and excess; cognitive impairment and neurodegenration with involvement of striatum and hippocampus. Neurotox. Res., 2008, 14(1), 45-56.
[http://dx.doi.org/10.1007/BF03033574] [PMID: 18790724]
[53]
Baumgartner, J.; Smuts, C.M.; Malan, L.; Kvalsvig, J.; van Stuijvenberg, M.E.; Hurrell, R.F.; Zimmermann, M.B. Effects of iron and n-3 fatty acid supplementation, alone and in combination, on cognition in school children: a randomized, double-blind, placebo-controlled intervention in South Africa. Am. J. Clin. Nutr., 2012, 96(6), 1327-1338.
[http://dx.doi.org/10.3945/ajcn.112.041004] [PMID: 23097272]
[54]
Prentice, A.M.; Mendoza, Y.A.; Pereira, D.; Cerami, C.; Wegmuller, R.; Constable, A.; Spieldenner, J. Dietary strategies for improving iron status: balancing safety and efficacy. Nutr. Rev., 2017, 75(1), 49-60.
[http://dx.doi.org/10.1093/nutrit/nuw055] [PMID: 27974599]
[55]
Zou, C.; Du, Y.; Rashid, A.; Ram, H.; Savasli, E.; Pieterse, P.J.; Ortiz-Monasterio, I.; Yazici, A.; Kaur, C.; Mahmood, K.; Singh, S.; Le Roux, M.R.; Kuang, W.; Onder, O.; Kalayci, M.; Cakmak, I. Simultaneous biofortification of wheat with zinc, iodine, selenium, and iron through foliar treatment of a micronutrient cocktail in six countries. J. Agric. Food Chem., 2019, 67(29), 8096-8106.
[http://dx.doi.org/10.1021/acs.jafc.9b01829] [PMID: 31260296]
[56]
Berglund, S.K.; Domellöf, M. Iron deficiency in infancy: Current insights. Curr. Opin. Clin. Nutr. Metab. Care, 2021, 24(3), 240-245.
[http://dx.doi.org/10.1097/MCO.0000000000000749] [PMID: 33656466]
[57]
Abuga, K.M.; Jones-Warner, W.; Hafalla, J.C.R. Immune responses to malaria pre-erythrocytic stages: Implications for vaccine development. Parasite Immunol., 2021, 43(2), e12795.
[http://dx.doi.org/10.1111/pim.12795] [PMID: 32981095]
[58]
Keats, E.C.; Charbonneau, K.D.; Das, J.K.; Bhutta, Z.A. Large-scale food fortification has great potential to improve child health and nutrition. Curr. Opin. Clin. Nutr. Metab. Care, 2021, 24(3), 271-275.
[http://dx.doi.org/10.1097/MCO.0000000000000745] [PMID: 33631771]
[59]
El-Mallah, C.A.; Beyh, Y.S.; Obeid, O.A. Iron fortification and supplementation: Fighting anemia of chronic diseases or fueling obesity? Curr. Dev. Nutr., 2021, 5(4), nzab032.
[http://dx.doi.org/10.1093/cdn/nzab032] [PMID: 33959691]
[60]
Trivedi, R.; Barve, K. Delivery systems for improving iron uptake in anemia. Int. J. Pharm., 2021, 601, 120590.
[http://dx.doi.org/10.1016/j.ijpharm.2021.120590] [PMID: 33845149]
[61]
Field, M.S.; Mithra, P.; Peña-Rosas, J.P. Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in populations. Cochrane Libr., 2021, 2021(1), CD011302.
[http://dx.doi.org/10.1002/14651858.CD011302.pub3] [PMID: 33461239]
[62]
Hertrampf, E.; Olivares, M. Iron amino acid chelates. Int. J. Vitam. Nutr. Res., 2004, 74(6), 435-443.
[http://dx.doi.org/10.1024/0300-9831.74.6.435] [PMID: 15743019]
[63]
Walter, T.; Hertrampf, E.; Pizarro, F.; Olivares, M.; Llaguno, S.; Letelier, A.; Vega, V.; Stekel, A. Effect of bovine-hemoglobin-fortified cookies on iron status of schoolchildren: a nationwide program in Chile. Am. J. Clin. Nutr., 1993, 57(2), 190-194.
[http://dx.doi.org/10.1093/ajcn/57.2.190] [PMID: 8424387]
[64]
Kawakami, Y.; Bhullar, N.K. Molecular processes in iron and zinc homeostasis and their modulation for biofortification in rice. J. Integr. Plant Biol., 2018, 60(12), 1181-1198.
[http://dx.doi.org/10.1111/jipb.12751] [PMID: 30468300]
[65]
Diego Quintaes, K.; Barberá, R.; Cilla, A. Iron bioavailability in iron-fortified cereal foods: The contribution of in vitro studies. Crit. Rev. Food Sci. Nutr., 2017, 57(10), 2028-2041.
[http://dx.doi.org/10.1080/10408398.2013.866543] [PMID: 25830598]
[66]
Olivares, M.; Walter, T.; Hertrampf, E.; Pizarro, F.; Stekel, A. Prevention of iron deficiency by milk fortification. The Chilean experience. Acta Paediatr., 1989, 78, 109-113.
[http://dx.doi.org/10.1111/apa.1989.78.s361.109] [PMID: 2485578]
[67]
Martorell, R.; de Romaña, D.L. Components of successful staple food fortification programs: Lessons from Latin America. Food Nutr. Bull., 2017, 38(3), 384-404.
[http://dx.doi.org/10.1177/0379572117707890] [PMID: 28490239]
[68]
Lachowicz, J.I.; Nurchi, V.M.; Fanni, D.; Gerosa, C.; Peana, M.; Zoroddu, M.A. Nutritional iron deficiency: the role of oral iron supplementation. Curr. Med. Chem., 2014, 21(33), 3775-3784.
[http://dx.doi.org/10.2174/0929867321666140706143925] [PMID: 25005180]
[69]
Nguyen, M.; Tadi, P. Acute Stroke; In Stat Pearls: Treasure Island, FL, 2022.
[70]
Tolkien, Z.; Stecher, L.; Mander, A.P.; Pereira, D.I.; Powell, J.J. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS One, 2015, 10(2), e0117383.
[http://dx.doi.org/10.1371/journal.pone.0117383]
[71]
Sen, A.; Kanani, S. Intermittent iron folate supplementation: impact on hematinic status and growth of school girls. ISRN Hematol, 2012, 2012, 482153.
[http://dx.doi.org/10.5402/2012/482153]
[72]
Ahmed, F.; Khan, M.R.; Akhtaruzzaman, M.; Karim, R.; Williams, G.; Banu, C.P.; Nahar, B.; Darnton-Hill, I. Effect of long-term intermittent supplementation with multiple micronutrients compared with iron-and-folic acid supplementation on Hb and micronutrient status of non-anaemic adolescent schoolgirls in rural Bangladesh. Br J Nutr, 2012, 108(8), 1484-1493.
[http://dx.doi.org/10.1017/S0007114511006908]
[73]
Bothwell, T.H. Iron requirements in pregnancy and strategies to meet them. Am. J. Clin. Nutr., 2000, 72(1), 257S-264S.
[http://dx.doi.org/10.1093/ajcn/72.1.257S] [PMID: 10871591]
[74]
Ford, F.A.; Mouratidou, T.; Wademan, S.E.; Fraser, R.B. Effect of the introduction of 'Healthy Start' on dietary behaviour during and after pregnancy: early results from the 'before and after' Sheffield study. Br. J. Nutr., 2009, 101(12), 1828-1836.
[75]
Caspersen, I.H.; Iglesias-Vazquez, L.; Abel, M.H.; Brantsaeter, A.L.; Arija, V.; Erlund, I.; Meltzer, H.M. Iron status in mid-pregnancy and associations with interpregnancy interval, hormonal contraceptives, dietary factors and supplement use. Br. J. Nutr., 2021, 126(8), 1270-1280.
[http://dx.doi.org/10.1017/S0007114521000295]
[76]
Casgrain, A.; Collings, R.; Harvey, L.J.; Hooper, L.; Fairweather-Tait, S.J. Effect of iron intake on iron status: a systematic review and meta-analysis of randomized controlled trials. Am. J. Clin. Nutr., 2012, 96(4), 768-780.
[http://dx.doi.org/10.3945/ajcn.112.040626] [PMID: 22932280]
[77]
Gera, T.; Sachdev, H.S.; Boy, E. Effect of iron-fortified foods on hematologic and biological outcomes: systematic review of randomized controlled trials. Am. J. Clin. Nutr., 2012, 96(2), 309-324.
[http://dx.doi.org/10.3945/ajcn.111.031500] [PMID: 22760566]
[78]
Muñoz, M.; Gómez-Ramírez, S.; Bhandari, S. The safety of available treatment options for iron-deficiency anemia. Expert Opin. Drug Saf., 2018, 17(2), 149-159.
[http://dx.doi.org/10.1080/14740338.2018.1400009] [PMID: 29103332]
[79]
Powers, J.M.; Buchanan, G.R. Disorders of iron metabolism. Hematol. Oncol. Clin. North Am., 2019, 33(3), 393-408.
[http://dx.doi.org/10.1016/j.hoc.2019.01.006] [PMID: 31030809]
[80]
Avni, T.; Bieber, A.; Grossman, A.; Green, H.; Leibovici, L.; Gafter-Gvili, A. The safety of intravenous iron preparations: systematic review and meta-analysis. Mayo Clin. Proc., 2015, 90(1), 12-23.
[http://dx.doi.org/10.1016/j.mayocp.2014.10.007] [PMID: 25572192]
[81]
Clevenger, B.; Gurusamy, K.; Klein, A.A.; Murphy, G.J.; Anker, S.D.; Richards, T. Systematic review and meta-analysis of iron therapy in anaemic adults without chronic kidney disease: Updated and abridged Cochrane review. Eur. J. Heart Fail., 2016, 18(7), 774-785.
[http://dx.doi.org/10.1002/ejhf.514] [PMID: 27121474]
[82]
Shrimpton, R.; Schultink, W.; Schultink, W. Can supplements help meet the micronutrient needs of the developing world? Proc. Nutr. Soc., 2002, 61(2), 223-229.
[http://dx.doi.org/10.1079/PNS2002163] [PMID: 12133204]
[83]
Means, R.T. Iron deficiency and iron deficiency anemia: Implications and impact in pregnancy, fetal development, and early childhood parameters. Nutrients, 2020, 12(2), 447.
[http://dx.doi.org/10.3390/nu12020447] [PMID: 32053933]
[84]
Ogawa, C.; Tsuchiya, K.; Maeda, K. Reticulocyte hemoglobin content. Clin. Chim. Acta, 2020, 504, 138-145.
[http://dx.doi.org/10.1016/j.cca.2020.01.032] [PMID: 32014518]
[85]
Porter, J.B. Iron through the prism of haematology. Br. J. Haematol., 2020, 191(4), 587-592.
[http://dx.doi.org/10.1111/bjh.17164] [PMID: 33190267]
[86]
Barffour, M.A.; Hinnouho, G.M.; Kounnavong, S.; Wessells, K.R.; Ratsavong, K.; Bounheuang, B.; Chanhthavong, B.; Sitthideth, D.; Sengnam, K.; Arnold, C.D.; Brown, K.H.; Hess, S.Y. Effects of daily zinc, daily multiple micronutrient powder, or therapeutic zinc supplementation for diarrhea prevention on physical growth, anemia, and micronutrient status in rural laotian children: A randomized controlled trial. J. Pediatr., 2019, 207, 80-89.e2.
[http://dx.doi.org/10.1016/j.jpeds.2018.11.022] [PMID: 30580974]
[87]
Nguyen, P.H.; Young, M.; Gonzalez-Casanova, I.; Pham, H.Q.; Nguyen, H.; Truong, T.V.; Nguyen, S.V.; Harding, K.B.; Reinhart, G.A.; Martorell, R.; Ramakrishnan, U. Impact of preconception micronutrient supplementation on anemia and iron status during pregnancy and postpartum: A randomized controlled trial in rural Vietnam. PLoS One, 2016, 11(12), e0167416.
[http://dx.doi.org/10.1371/journal.pone.0167416] [PMID: 27918586]
[88]
Jáuregui-Lobera, I. Iron deficiency and cognitive functions. Neuropsychiatr. Dis. Treat., 2014, 10, 2087-2095.
[http://dx.doi.org/10.2147/NDT.S72491] [PMID: 25419131]
[89]
World Health Organization (WHO). Guideline:Fortification of Maize Flour and Corn Meal with Vitamins and Minerals; Geneva, 2016.

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