Login Register Cart 0
Generic placeholder image

Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Propolis: Antineoplastic Activity, Constituents, and Mechanisms of Action

Author(s): Patricia Ruiz-Bustos, Efrain Alday, Adriana Garibay-Escobar, José Maurício Sforcin, Yulia Lipovka, Javier Hernandez and Carlos Velazquez*

Volume 23, Issue 18, 2023

Published on: 16 May, 2023

Page: [1753 - 1764] Pages: 12

DOI: 10.2174/1568026623666230321120631

Price: $65

Abstract

Propolis is a beehive product with great pharmacological potential, including antineoplastic activity.

Objectives: The aim of this study is to provide an actual understanding of the existent scientific information regarding the antiproliferative effect of propolis, proposed mechanisms of action, and challenges to meet.

Methods: An assessment of the scientific literature was attained using the PubMed and SciFinder platforms. Research papers, clinical trials, and reviews published between the years 2000 - 2021, were considered. The words “anticancer”, “antitumor”, “antiproliferative” and “propolis” were used in the search criteria.

Conclusion: A summary of several antiproliferative activities of different types of propolis is exposed. The potential health benefits of propolis are discussed. The variable plant origin of propolis partially accounts for its anti-cancer activities. Even when some mechanisms of action of propolis have been proposed, much of the genesis of how this effect is produced is yet to be answered, including several molecular mechanisms in different biological systems.

Keywords: Propolis, Antiproliferative, Anticancer, Antitumor, Chemical composition, Mechanisms.

« Previous Next »
Graphical Abstract

[1]
Bankova, V. Recent trends and important developments in propolis research. Evid. Based Complement. Alternat. Med., 2005, 2(1), 29-32.
[http://dx.doi.org/10.1093/ecam/neh059] [PMID: 15841275]
[2]
Castaldo, S.; Capasso, F. Propolis, an old remedy used in modern medicine. Fitoterapia, 2002, 73(S1), S1-S6.
[http://dx.doi.org/10.1016/S0367-326X(02)00185-5] [PMID: 12495704]
[3]
Cornara, L.; Biagi, M.; Xiao, J.; Burlando, B. Therapeutic properties of bioactive compounds from different honeybee products. Front. Pharmacol., 2017, 8, 412.
[http://dx.doi.org/10.3389/fphar.2017.00412] [PMID: 28701955]
[4]
Sforcin, J.M.; Bankova, V. Propolis: Is there a potential for the development of new drugs? J. Ethnopharmacol., 2011, 133(2), 253-260.
[http://dx.doi.org/10.1016/j.jep.2010.10.032] [PMID: 20970490]
[5]
Alday, E.; Valencia, D.; Garibay-Escobar, A.; Domínguez-Esquivel, Z.; Piccinelli, A.L.; Rastrelli, L.; Monribot-Villanueva, J.; Guerrero-Analco, J.A.; Robles-Zepeda, R.E.; Hernandez, J.; Velazquez, C. Plant origin authentication of Sonoran Desert propolis: an antiproliferative propolis from a semi-arid region. Naturwissenschaften, 2019, 106(5-6), 25.
[http://dx.doi.org/10.1007/s00114-019-1620-2] [PMID: 31069518]
[6]
Velazquez, C.; Navarro, M.; Acosta, A.; Angulo, A.; Dominguez, Z.; Robles, R.; Robles-Zepeda, R.; Lugo, E.; Goycoolea, F.M.; Velazquez, E.F.; Astiazaran, H.; Hernandez, J. Antibacterial and free-radical scavenging activities of Sonoran propolis. J. Appl. Microbiol., 2007, 103(5), 1747-1756.
[http://dx.doi.org/10.1111/j.1365-2672.2007.03409.x] [PMID: 17953585]
[7]
Przybyłek, I.; Karpiński, T.M. Antibacterial properties of propolis. Molecules, 2019, 24(11), 2047.
[http://dx.doi.org/10.3390/molecules24112047] [PMID: 31146392]
[8]
Martorano-Fernandes, L.; Cavalcanti, Y. W.; de Almeida, L. Inhibitory effect of Brazilian red propolis on Candida biofilms developed on titanium surfaces. BMC Complement Med Ther, 2020, 20(104), 2047.
[http://dx.doi.org/10.1186/s12906-020-02893-9] [PMID: 32245474]
[9]
Osés, S.M.; Marcos, P.; Azofra, P.; de Pablo, A.; Fernández-Muíño, M.Á.; Sancho, M.T. Phenolic profile, antioxidant capacities and enzymatic inhibitory activities of propolis from different geographical areas: Needs for analytical harmonization. Antioxidants, 2020, 9(1), 75.
[http://dx.doi.org/10.3390/antiox9010075] [PMID: 31952253]
[10]
Kocot, J. Kiełczykowska, M.; Luchowska-Kocot, D.; Kurzepa, J.; Musik, I. Antioxidant potential of propolis, bee pollen, and royal jelly: Possible medical application. Oxid. Med. Cell. Longev., 2018, 20187074209
[http://dx.doi.org/10.1155/2018/7074209]
[11]
Alday-Provencio, S.; Diaz, G.; Rascon, L.; Quintero, J.; Alday, E.; Robles-Zepeda, R.; Garibay-Escobar, A.; Astiazaran, H.; Hernandez, J.; Velazquez, C. Sonoran propolis and some of its chemical constituents inhibit in vitro growth of Giardia lamblia trophozoites. Planta Med., 2015, 81(9), 742-747.
[http://dx.doi.org/10.1055/s-0035-1545982] [PMID: 26008200]
[12]
Sforcin, J.M. Biological properties and therapeutic applications of propolis. Phytother. Res., 2016, 30(6), 894-905.
[http://dx.doi.org/10.1002/ptr.5605] [PMID: 26988443]
[13]
Alday, E.; Navarro-Navarro, M.; Garibay-Escobar, A.; Robles-Zepeda, R.; Hernandez, J.; Velazquez, C. Advances in pharmacological activities and chemical composition of propolis produced in Americas. In: Beekeeping and Bee Conservation-Advances in Research;, 2016.
[http://dx.doi.org/10.5772/63145]
[14]
Falcão, S.I.; Calhelha, R.C.; Touzani, S.; Lyoussi, B.; Ferreira, I.C.F.R.; Vilas-Boas, M. In vitro interactions of moroccan propolis phytochemical’s on human tumor cell lines and anti-inflammatory properties. Biomolecules, 2019, 9(8), 315.
[http://dx.doi.org/10.3390/biom9080315] [PMID: 31362402]
[15]
Ratnieks, F.L.W.; Shackleton, K. Does the waggle dance help honey bees to forage at greater distances than expected for their body size? Front. Ecol. Evol., 2015, 3, 31.
[http://dx.doi.org/10.3389/fevo.2015.00031]
[16]
Galeotti, F.; Maccari, F.; Fachini, A.; Volpi, N. Chemical composition and antioxidant activity of propolis prepared in different forms and in different solvents useful for finished products. Foods, 2018, 7(3), 41.
[http://dx.doi.org/10.3390/foods7030041] [PMID: 29562665]
[17]
Wilson, M.B.; Spivak, M.; Hegeman, A.D.; Rendahl, A.; Cohen, J.D. Metabolomics reveals the origins of antimicrobial plant resins collected by honey bees. PLoS One, 2013, 8(10)e77512
[http://dx.doi.org/10.1371/journal.pone.0077512] [PMID: 24204850]
[18]
Globocan Key Facts. Available from: https://gco.iarc.fr/today/data/factsheets/cancers/39-All-cancers-fact-sheet.pdf (Accessed on: 16 Oct 2021).
[19]
Wang, J.J.; Lei, K.F.; Han, F. Tumor microenvironment: recent advances in various cancer treatments. Eur. Rev. Med. Pharmacol. Sci., 2018, 22(12), 3855-3864.
[PMID: 29949179]
[20]
Christov, R.; Trusheva, B.; Popova, M.; Bankova, V.; Bertrand, M. Chemical composition of propolis from Canada, its antiradical activity and plant origin. Nat. Prod. Res., 2006, 20(6), 531-536.
[http://dx.doi.org/10.1080/14786410500056918] [PMID: 16835083]
[21]
Hernandez, J.; Goycoolea, F.; Quintero, J.; Acosta, A.; Castañeda, M.; Dominguez, Z.; Robles, R.; Vazquez-Moreno, L.; Velazquez, E.; Astiazaran, H.; Lugo, E.; Velazquez, C. Sonoran propolis: chemical composition and antiproliferative activity on cancer cell lines. Planta Med., 2007, 73(14), 1469-1474.
[http://dx.doi.org/10.1055/s-2007-990244] [PMID: 17948188]
[22]
Alday, E.; Valencia, D.; Carreño, A.L.; Picerno, P.; Piccinelli, A.L.; Rastrelli, L.; Robles-Zepeda, R.; Hernandez, J.; Velazquez, C. Apoptotic induction by pinobanksin and some of its ester derivatives from Sonoran propolis in a B-cell lymphoma cell line. Chem. Biol. Interact., 2015, 242, 35-44.
[http://dx.doi.org/10.1016/j.cbi.2015.09.013] [PMID: 26367700]
[23]
Valencia, D.; Alday, E.; Robles-Zepeda, R.; Garibay-Escobar, A.; Galvez-Ruiz, J.C.; Salas-Reyes, M.; Jiménez-Estrada, M.; Velazquez-Contreras, E.; Hernandez, J.; Velazquez, C. Seasonal effect on chemical composition and biological activities of Sonoran propolis. Food Chem., 2012, 131(2), 645-651.
[http://dx.doi.org/10.1016/j.foodchem.2011.08.086]
[24]
Frión-Herrera, Y.; Díaz-García, A.; Ruiz-Fuentes, J.; Rodríguez-Sánchez, H.; Sforcin, J.M. The cytotoxic effects of propolis on breast cancer cells involve PI3K/Akt and ERK1/2 pathways, mitochondrial membrane potential, and reactive oxygen species generation. Inflammopharmacology, 2019, 27(5), 1081-1089.
[http://dx.doi.org/10.1007/s10787-018-0492-y] [PMID: 29748880]
[25]
Cuesta-Rubio, O.; Piccinelli, A.L.; Campo Fernandez, M.; Márquez Hernández, I.; Rosado, A.; Rastrelli, L. Chemical characterization of Cuban propolis by HPLC-PDA, HPLC-MS, and NMR: the brown, red, and yellow Cuban varieties of propolis. J. Agric. Food Chem., 2007, 55(18), 7502-7509.
[http://dx.doi.org/10.1021/jf071296w] [PMID: 17691806]
[26]
Pardo-Mora, D.P.; Murillo, O.J.; Rey-Buitrago, M.; Losada-Barragán, M.; Uribe, J.F.C.; Santiago, K.B.; Conti, B.J.; Cardoso, E.O.; Conte, F.L.; Gutiérrez, R.M.; García, O.T.; Sforcin, J.M. Apoptosis-related gene expression induced by Colombian propolis samples in canine osteosarcoma cell line. Vet. World, 2021, 14(4), 964-971.
[http://dx.doi.org/10.14202/vetworld.2021.964-971] [PMID: 34083947]
[27]
Mora, D.P.P.; Santiago, K.B.; Conti, B.J.; de Oliveira Cardoso, E.; Conte, F.L.; Oliveira, L.P.G.; de Assis Golim, M.; Uribe, J.F.C.; Gutiérrez, R.M.; Buitrago, M.R.; Popova, M.; Trusheva, B.; Bankova, V.; García, O.T.; Sforcin, J.M. The chemical composition and events related to the cytotoxic effects of propolis on osteosarcoma cells: A comparative assessment of Colombian samples. Phytother. Res., 2019, 33(3), 591-601.
[http://dx.doi.org/10.1002/ptr.6246] [PMID: 30488503]
[28]
Cinegaglia, N.C.; Bersano, P.R.O.; Búfalo, M.C.; Sforcin, J.M. Cytotoxic action of Brazilian propolis in vitro on canine osteosarcoma cells. Phytother. Res., 2013, 27(9), 1277-1281.
[http://dx.doi.org/10.1002/ptr.4861] [PMID: 23074147]
[29]
Li, H.; Kapur, A.; Yang, J.; Srivastava, S.; McLeod, D.; Paredes-Guzman, J.; Daugsch, A.; Park, Y.; Rhim, J. Antiproliferation of human prostate cancer cells by ethanolic extracts of Brazilian propolis and its botanical origin. Int. J. Oncol., 2007, 31(3), 601-606.
[http://dx.doi.org/10.3892/ijo.31.3.601] [PMID: 17671687]
[30]
Machado, B.A.S.; Silva, R.P.D.; Barreto, G.A.; Costa, S.S.; Silva, D.F.; Brandão, H.N.; Rocha, J.L.C.; Dellagostin, O.A.; Henriques, J.A.P.; Umsza-Guez, M.A.; Padilha, F.F. Chemical composition and biological activity of extracts obtained by supercritical extraction and ethanolic extraction of brown, green and red propolis derived from different geographic regions in Brazil. PLoS One, 2016, 11(1)e0145954
[http://dx.doi.org/10.1371/journal.pone.0145954] [PMID: 26745799]
[31]
Kano, Y.; Horie, N.; Doi, S.; Aramaki, F.; Maeda, H.; Hiragami, F.; Kawamura, K.; Motoda, H.; Koike, Y.; Akiyama, J.; Eguchi, S.; Hashimoto, K. Artepillin C derived from propolis induces neurite outgrowth in PC12m3 cells via ERK and p38 MAPK pathways. Neurochem. Res., 2008, 33(9), 1795-1803.
[http://dx.doi.org/10.1007/s11064-008-9633-9] [PMID: 18338254]
[32]
de Mendonça, I.C.G.; Porto, I.C.C.M.; do Nascimento, T.G.; de Souza, N.S.; Oliveira, J.M.S.; Arruda, R.E.S.; Mousinho, K.C.; dos Santos, A.F.; Basílio-Júnior, I.D.; Parolia, A.; Barreto, F.S. Brazilian red propolis: phytochemical screening, antioxidant activity and effect against cancer cells. BMC Complement. Altern. Med., 2015, 15(1), 357.
[http://dx.doi.org/10.1186/s12906-015-0888-9] [PMID: 26467757]
[33]
da Silva Frozza, C.O.; Garcia, C.S.C.; Gambato, G.; de Souza, M.D.O.; Salvador, M.; Moura, S.; Padilha, F.F.; Seixas, F.K.; Collares, T.; Borsuk, S.; Dellagostin, O.A.; Henriques, J.A.P.; Roesch-Ely, M. Chemical characterization, antioxidant and cytotoxic activities of Brazilian red propolis. Food Chem. Toxicol., 2013, 52, 137-142.
[http://dx.doi.org/10.1016/j.fct.2012.11.013] [PMID: 23174518]
[34]
Kamiya, T.; Nishihara, H.; Hara, H.; Adachi, T. Ethanol extract of Brazilian red propolis induces apoptosis in human breast cancer MCF-7 cells through endoplasmic reticulum stress. J. Agric. Food Chem., 2012, 60(44), 11065-11070.
[http://dx.doi.org/10.1021/jf303004n] [PMID: 23066995]
[35]
Begnini, K.R.; Moura de Leon, P.M.; Thurow, H.; Schultze, E.; Campos, V.F.; Martins Rodrigues, F.; Borsuk, S.; Dellagostin, O.A.; Savegnago, L.; Roesch-Ely, M. Brazilian red propolis induces apoptosis-like cell death and decreases migration potential in bladder cancer cells. Evid. Based Complement. Alternat. Med., 2014, 2014639856
[http://dx.doi.org/10.1155/2014/639856]
[36]
Ribeiro, D.R.; Alves, Â.V.F.; dos Santos, E.P.; Padilha, F.F.; Gomes, M.Z.; Rabelo, A.S.; Cardoso, J.C.; Massarioli, A.P.; de Alencar, S.M.; de Albuquerque-Júnior, R.L.C. Inhibition of DMBA-induced oral squamous cells carcinoma growth by brazilian red propolis in rodent model. Basic Clin. Pharmacol. Toxicol., 2015, 117(2), 85-95.
[http://dx.doi.org/10.1111/bcpt.12374] [PMID: 25556639]
[37]
Žižić J.B.; Vuković N.L.; Jadranin, M.B.; Anđelković, B.D.; Tešević V.V.; Kacaniova, M.M.; Sukdolak, S.B.; Marković S.D. Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line. J. Sci. Food Agric., 2013, 93(12), 3001-3009.
[http://dx.doi.org/10.1002/jsfa.6132] [PMID: 23504630]
[38]
Popova, M.; Giannopoulou, E. Skalicka-Woźniak, K.; Graikou, K.; Widelski, J.; Bankova, V.; Kalofonos, H.; Sivolapenko, G.; Gaweł-Bęben, K.; Antosiewicz, B.; Chinou, I. Characterization and biological evaluation of propolis from Poland. Molecules, 2017, 22(7), 1159.
[http://dx.doi.org/10.3390/molecules22071159] [PMID: 28696397]
[39]
Wezgowiec, J.; Wieczynska, A.; Wieckiewicz, W.; Kulbacka, J.; Saczko, J.; Pachura, N.; Wieckiewicz, M.; Gancarz, R.; Wilk, K.A. Polish propolis-Chemical composition and biological effects in tongue cancer cells and macrophages. Molecules, 2020, 25(10), 2426.
[http://dx.doi.org/10.3390/molecules25102426] [PMID: 32455950]
[40]
Borawska, M.H.; Naliwajko, S.K.; Moskwa, J. Markiewicz-Żukowska, R.; Puścion-Jakubik, A.; Soroczyńska, J. Anti-proliferative and anti-migration effects of Polish propolis combined with Hypericum perforatum L. on glioblastoma multiforme cell line U87MG. BMC Complement. Altern. Med., 2016, 16(1), 367.
[http://dx.doi.org/10.1186/s12906-016-1351-2] [PMID: 27647142]
[41]
Barbarić M.; Mišković K.; Bojić M.; Lončar, M.B.; Smolčić-Bubalo, A.; Debeljak, Ž.; Medić-Šarić M. Chemical composition of the ethanolic propolis extracts and its effect on HeLa cells. J. Ethnopharmacol., 2011, 135(3), 772-778.
[http://dx.doi.org/10.1016/j.jep.2011.04.015] [PMID: 21515353]
[42]
Pratsinis, H.; Kletsas, D.; Melliou, E.; Chinou, I. Antiproliferative activity of Greek propolis. J. Med. Food, 2010, 13(2), 286-290.
[http://dx.doi.org/10.1089/jmf.2009.0071] [PMID: 20132046]
[43]
Silva-Carvalho, R.; Miranda-Gonçalves, V.; Ferreira, A.M.; Cardoso, S.M.; Sobral, A.J.; Almeida-Aguiar, C.; Baltazar, F. Antitumoural and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models. J. Funct. Foods, 2014, 11, 160-171.
[44]
Elnakady, Y.A.; Rushdi, A.I.; Franke, R.; Abutaha, N.; Ebaid, H.; Baabbad, M.; Omar, M.O.M.; Al Ghamdi, A.A. Characteristics, chemical compositions and biological activities of propolis from Al-Bahah, Saudi Arabia. Sci. Rep., 2017, 7(1), 41453.
[http://dx.doi.org/10.1038/srep41453] [PMID: 28165013]
[45]
Xuan, H.; Li, Z.; Yan, H.; Sang, Q.; Wang, K.; He, Q.; Wang, Y.; Hu, F. Antitumor activity of chinese propolis in human breast cancer MCF-7 and MDA-MB-231 Cells. Evid. Based Complement. Alternat. Med., 2014, 2014, 1-11.
[http://dx.doi.org/10.1155/2014/280120] [PMID: 24963320]
[46]
Zheng, Y.; Wu, Y.; Chen, X.; Jiang, X.; Wang, K.; Hu, F. Chinese propolis exerts anti-proliferation effects in human melanoma cells by targeting NLRP1 inflammatory pathway, inducing apoptosis, cell cycle arrest, and autophagy. Nutrients, 2018, 10(9), 1170.
[http://dx.doi.org/10.3390/nu10091170] [PMID: 30149677]
[47]
Xuan, H.; Wang, Y.; Li, A.; Fu, C.; Wang, Y.; Peng, W. Bioactive components of chinese propolis water extract on antitumor activity and quality control. Evid. Based Complement. Alternat. Med., 2016, 20169641965
[http://dx.doi.org/10.1155/2016/9641965]
[48]
Khacha-ananda, S.; Tragoolpua, K.; Chantawannakul, P.; Tragoolpua, Y. Propolis extracts from the northern region of Thailand suppress cancer cell growth through induction of apoptosis pathways. Invest. New Drugs, 2016, 34(6), 707-722.
[http://dx.doi.org/10.1007/s10637-016-0392-1] [PMID: 27655216]
[49]
Teerasripreecha, D.; Phuwapraisirisan, P.; Puthong, S.; Kimura, K.; Okuyama, M.; Mori, H.; Kimura, A.; Chanchao, C. In vitro antiproliferative/cytotoxic activity on cancer cell lines of a cardanol and a cardol enriched from Thai Apis mellifera propolis. BMC Complement. Altern. Med., 2012, 12(1), 27.
[http://dx.doi.org/10.1186/1472-6882-12-27] [PMID: 22458642]
[50]
Tartik, M.; Darendelioglu, E.; Aykutoglu, G.; Baydas, G. Turkish propolis supresses MCF-7 cell death induced by homocysteine. Biomed. Pharmacother., 2016, 82, 704-712.
[http://dx.doi.org/10.1016/j.biopha.2016.06.013] [PMID: 27470414]
[51]
Demir, S.; Aliyazicioglu, Y.; Turan, I.; Misir, S.; Mentese, A.; Yaman, S.O.; Akbulut, K.; Kilinc, K.; Deger, O. Antiproliferative and proapoptotic activity of Turkish propolis on human lung cancer cell line. Nutr. Cancer, 2016, 68(1), 165-172.
[http://dx.doi.org/10.1080/01635581.2016.1115096] [PMID: 26700423]
[52]
Turan, I.; Demir, S.; Misir, S.; Kilinc, K.; Mentese, A.; Aliyazicioglu, Y.; Deger, O. Cytotoxic effect of Turkish propolis on liver, colon, breast, cervix and prostate cancer cell lines. Trop. J. Pharm. Res., 2015, 14(5), 777-782.
[http://dx.doi.org/10.4314/tjpr.v14i5.5]
[53]
Misir, S.; Aliyazicioglu, Y.; Demir, S.; Turan, I.; Hepokur, C. Effect of Turkish Propolis on miRNA expression, cell cycle, and apoptosis in human breast cancer (MCF-7) Cells. Nutr. Cancer, 2020, 72(1), 133-145.
[http://dx.doi.org/10.1080/01635581.2019.1616100] [PMID: 31112051]
[54]
Iqbal, M.; Fan, T.; Watson, D.; Alenezi, S.; Saleh, K.; Sahlan, M. Preliminary studies: the potential anti-angiogenic activities of two Sulawesi Island (Indonesia) propolis and their chemical characterization. Heliyon, 2019, 5(7)e01978
[http://dx.doi.org/10.1016/j.heliyon.2019.e01978] [PMID: 31372523]
[55]
Trusheva, B.; Popova, M.; Koendhori, E.B.; Tsvetkova, I.; Naydenski, C.; Bankova, V. Indonesian propolis: chemical composition, biological activity and botanical origin. Nat. Prod. Res., 2011, 25(6), 606-613.
[http://dx.doi.org/10.1080/14786419.2010.488235] [PMID: 21409722]
[56]
Weng, M.S.; Liao, C.H.; Chen, C.N.; Wu, C.L.; Lin, J.K. Propolin H from Taiwanese propolis induces G1 arrest in human lung carcinoma cells. J. Agric. Food Chem., 2007, 55(13), 5289-5298.
[http://dx.doi.org/10.1021/jf070201n] [PMID: 17530771]
[57]
Huang, W.J.; Huang, C.H.; Wu, C.L.; Lin, J.K.; Chen, Y.W.; Lin, C.L.; Chuang, S.E.; Huang, C.Y.; Chen, C.N.; Propolin, G. Propolin G, a prenylflavanone, isolated from Taiwanese propolis, induces caspase-dependent apoptosis in brain cancer cells. J. Agric. Food Chem., 2007, 55(18), 7366-7376.
[http://dx.doi.org/10.1021/jf0710579] [PMID: 17685631]
[58]
Taira, N.; Nguyen, B.C.Q.; Be Tu, P.T.; Tawata, S. Effect of Okinawa propolis on PAK1 activity, Caenorhabditis elegans longevity, melanogenesis, and growth of cancer cells. J. Agric. Food Chem., 2016, 64(27), 5484-5489.
[http://dx.doi.org/10.1021/acs.jafc.6b01785] [PMID: 27337169]
[59]
Alizadeh, A.M.; Afrouzan, H.; Dinparast-Djadid, N.; Sawaya, A.C.F.; Azizian, S.; Hemmati, H.R.; Mohagheghi, M.A.; Erfani, S. Chemoprotection of MNNG-initiated gastric cancer in rats using Iranian propolis. Arch. Iran Med., 2015, 18(1), 18-23.
[60]
Kapare, H.; Lohidasan, S.; Sinnathambi, A.; Mahadik, K. Standardization, anti-carcinogenic potential and biosafety of Indian propolis. J. Ayurveda Integr. Med., 2019, 10(2), 81-87.
[http://dx.doi.org/10.1016/j.jaim.2017.06.003] [PMID: 29217339]
[61]
Zingue, S.; Maxeiner, S.; Rutz, J.; Ndinteh, D.T.; Chun, F.K.H.; Fohouo, F.N.T.; Njamen, D.; Blaheta, R.A. Ethanol-extracted Cameroonian propolis: Antiproliferative effects and potential mechanism of action in prostate cancer. Andrologia, 2020, 52(9)e13698
[http://dx.doi.org/10.1111/and.13698] [PMID: 32573810]
[62]
Vernyuy, T.P.; Ngenge, T.A.; Carol, D.M.E.; Emmanuel, T.; Joseph, M.T.; Popova, M.; Bankova, V. Chemical constituents and anti-ulcer activity of propolis from the North-West region of Cameroon. Res. J. Phytochem., 2016, 10(2), 45-57.
[http://dx.doi.org/10.3923/rjphyto.2016.45.57]
[63]
Bankova, V.; Popova, M.; Trusheva, B. Propolis volatile compounds: chemical diversity and biological activity: a review. Chem. Cent. J., 2014, 8(1), 28.
[http://dx.doi.org/10.1186/1752-153X-8-28] [PMID: 24812573]
[64]
Kouidhi, B.; Zmantar, T.; Bakhrouf, A. Anti-cariogenic and anti-biofilms activity of Tunisian propolis extract and its potential protective effect against cancer cells proliferation. Anaerobe, 2010, 16(6), 566-571.
[http://dx.doi.org/10.1016/j.anaerobe.2010.09.005] [PMID: 20934525]
[65]
El-khawaga, O.A.Y.; Salem, T.A.; Elshal, M.F. Protective role of Egyptian propolis against tumor in mice. Clin. Chim. Acta, 2003, 338(1-2), 11-16.
[http://dx.doi.org/10.1016/S0009-8981(03)00323-1] [PMID: 14637260]
[66]
Georgieva, K.; Trusheva, B.; Uzunova, V.; Stoyanova, T.; Valcheva, V.; Popova, M.; Tzoneva, R.; Bankova, V. New cycloartane triterpenes from bioactive extract of propolis from Pitcairn Island. Fitoterapia, 2018, 128, 233-241.
[http://dx.doi.org/10.1016/j.fitote.2018.05.024] [PMID: 29800610]
[67]
Catchpole, O.; Mitchell, K.; Bloor, S.; Davis, P.; Suddes, A. Antiproliferative activity of New Zealand propolis and phenolic compounds vs. human colorectal adenocarcinoma cells. Fitoterapia, 2015, 106, 167-174.
[http://dx.doi.org/10.1016/j.fitote.2015.09.004] [PMID: 26347954]
[68]
Bloor, S.; Catchpole, O.; Mitchell, K.; Webby, R.; Davis, P. Antiproliferative Acylated Glycerols from New Zealand Propolis. J. Nat. Prod., 2019, 82(9), 2359-2367.
[http://dx.doi.org/10.1021/acs.jnatprod.8b00562] [PMID: 31429567]
[69]
Massaro, C.F.; Simpson, J.B.; Powell, D.; Brooks, P. Chemical composition and antimicrobial activity of honeybee (Apis mellifera ligustica) propolis from subtropical eastern Australia. Naturwissenschaften, 2015, 102(11-12), 68.
[http://dx.doi.org/10.1007/s00114-015-1318-z] [PMID: 26521267]
[70]
Picazo-Aragonés, J.; Terrab, A.; Balao, F. Plant volatile organic compounds evolution: transcriptional regulation, epigenetics and polyploidy. Int. J. Mol. Sci., 2020, 21(23), 8956.
[http://dx.doi.org/10.3390/ijms21238956] [PMID: 33255749]
[71]
Leonhardt, S.D.; Zeilhofer, S.; Blüthgen, N.; Schmitt, T. Stingless bees use terpenes as olfactory cues to find resin sources. Chem. Senses, 2010, 35(7), 603-611.
[http://dx.doi.org/10.1093/chemse/bjq058] [PMID: 20534774]
[72]
Blicharska, N.; Seidel, V. Chemical Diversity and Biological Activity of African Propolis. Prog. Chem. Org. Nat. Prod., 2019, 109, 415-450.
[http://dx.doi.org/10.1007/978-3-030-12858-6_3] [PMID: 31637531]
[73]
Simone-Finstrom, M.; Borba, R.; Wilson, M.; Spivak, M. Propolis counteracts some threats to honey bee health. Insects, 2017, 8(2), 46.
[http://dx.doi.org/10.3390/insects8020046] [PMID: 28468244]
[74]
Bankova, V.; Galabov, A.S.; Antonova, D.; Vilhelmova, N.; Di Perri, B. Chemical composition of Propolis Extract ACF® and activity against herpes simplex virus. Phytomedicine, 2014, 21(11), 1432-1438.
[http://dx.doi.org/10.1016/j.phymed.2014.04.026] [PMID: 25022206]
[75]
Mohtar, L.G.; Rodríguez, S.A.; Nazareno, M.A. Comparative analysis of volatile compound profiles of propolis from different provenances. J. Sci. Food Agric., 2018, 98(9), 3409-3415.
[http://dx.doi.org/10.1002/jsfa.8852] [PMID: 29280145]
[76]
Salatino, A.; Teixeira, É.W.; Negri, G.; Message, D. Origin and chemical variation of Brazilian propolis. Evid. Based Complement. Alternat. Med., 2005, 2(1), 33-38.
[http://dx.doi.org/10.1093/ecam/neh060] [PMID: 15841276]
[77]
Agüero, M.B.; Svetaz, L.; Sánchez, M.; Luna, L.; Lima, B.; López, M.L.; Zacchino, S.; Palermo, J.; Wunderlin, D.; Feresin, G.E.; Tapia, A. Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae). HPLC–MS and GC–MS characterization and antifungal activity. Food Chem. Toxicol., 2011, 49(9), 1970-1978.
[http://dx.doi.org/10.1016/j.fct.2011.05.008] [PMID: 21600954]
[78]
Pino, J.A.; Marbot, R.; Delgado, A.; Zumárraga, C.; Sauri, E. Volatile constituents of propolis from honey bees and stingless bees from Yucatan. J. Essent. Oil Res., 2006, 18(1), 53-56.
[http://dx.doi.org/10.1080/10412905.2006.9699384]
[79]
Jerković I.; Mastelić J. Volatile compounds from leaf-buds of Populus nigra L. (Salicaceae). Phytochemistry, 2003, 63(1), 109-113.
[http://dx.doi.org/10.1016/S0031-9422(02)00706-9] [PMID: 12657305]
[80]
Milos, M.; Radonic, A.; Mastelic, J. Seasonal variation in essential oil compositions of Cupressus sempervirens L. J. Essent. Oil Res., 2002, 14(3), 222-223.
[http://dx.doi.org/10.1080/10412905.2002.9699829]
[81]
Gomes, P.B.; Mata, V.G.; Rodrigues, A.E. Characterization of the Portuguese-grown Cistus ladanifer essential oil. J. Essent. Oil Res., 2005, 17(2), 160-165.
[http://dx.doi.org/10.1080/10412905.2005.9698864]
[82]
Bankova, V.S.; Christov, R.; Tejera, A.D. Lignans and other constituents of propolis from the canary islands. Phytochemistry, 1998, 49(5), 1411-1415.
[http://dx.doi.org/10.1016/S0031-9422(98)00108-3]
[83]
Haile, K.; Kebede, T.; Dekebo, A. A comparative study of volatile components of propolis (bee glue) collected from Haramaya University and Assela Beekeeping Centers, Ethiopia. Bull. Chem. Soc. Ethiop., 2012, 26(3), 353-360.
[http://dx.doi.org/10.4314/bcse.v26i3.4]
[84]
Greenaway, W.; Scaysbrook, T.; Whatley, F.R. Headspace volatiles from propolis. Flavour Fragrance J., 1989, 4(4), 173-175.
[http://dx.doi.org/10.1002/ffj.2730040404]
[85]
Hames-Kocabas, E.E.; Demirci, B.; Uzel, A.; Demirci, F. Volatile composition of Anatolian propolis by headspace-solid-phase microextraction (HS-SPME), antimicrobial activity against food contaminants and antioxidant activity. J. Med. Plants Res., 2013, 7(28), 2140-2149.
[http://dx.doi.org/10.5897/JMPR2013.4470]
[86]
Naik, D.G.; Vaidya, H.S.; Namjoshi, T.P. Essential oil of Indian propolis: chemical composition and repellency against the honeybee Apis florea. Chem. Biodivers., 2013, 10(4), 649-657.
[http://dx.doi.org/10.1002/cbdv.201200165] [PMID: 23576351]
[87]
Popolo, A.; Piccinelli, A.L.; Morello, S.; Sorrentino, R.; Osmany, C.R.; Rastrelli, L.; Aldo, P. Cytotoxic activity of nemorosone in human MCF-7 breast cancer cells. Can. J. Physiol. Pharmacol., 2011, 89(1), 50-57.
[http://dx.doi.org/10.1139/Y10-100] [PMID: 21186377]
[88]
Frión-Herrera, Y.; Gabbia, D.; Díaz-García, A.; Cuesta-Rubio, O.; Carrara, M. Chemosensitizing activity of Cuban propolis and nemorosone in doxorubicin resistant human colon carcinoma cells. Fitoterapia, 2019, 136104173
[http://dx.doi.org/10.1016/j.fitote.2019.104173] [PMID: 31085307]
[89]
Endo, S.; Hoshi, M.; Matsunaga, T.; Inoue, T.; Ichihara, K.; Ikari, A. Autophagy inhibition enhances anticancer efficacy of artepillin C, a cinnamic acid derivative in Brazilian green propolis. Biochem. Biophys. Res. Commun., 2018, 497(1), 437-443.
[http://dx.doi.org/10.1016/j.bbrc.2018.02.105] [PMID: 29452093]
[90]
Wang, C.C.; Wang, Y.X.; Yu, N.Q.; Hu, D.; Wang, X.Y.; Chen, X.G.; Liao, Y.W.; Yao, J.; Wang, H.; He, L.; Wu, L. Brazilian green propolis extract synergizes with Protoporphyrin IX-mediated photodynamic therapy via enhancement of intracellular accumulation of protoporphyrin ix and attenuation of NF-κB and COX-2. Molecules, 2017, 22(5), 732.
[http://dx.doi.org/10.3390/molecules22050732] [PMID: 28471399]
[91]
Alsherbiny, M.A.; Bhuyan, D.J.; Radwan, I.; Chang, D.; Li, C.G. Metabolomic identification of anticancer metabolites of australian propolis and proteomic elucidation of its synergistic mechanisms with doxorubicin in the MCF7 Cells. Int. J. Mol. Sci., 2021, 22(15), 7840.
[http://dx.doi.org/10.3390/ijms22157840] [PMID: 34360606]

Rights & Permissions Print Cite
Article Metrics
57
2
Wayfinder Image
© 2024 Bentham Science Publishers | Privacy Policy