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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Clinical Trial

同步放化疗联合尼莫单抗治疗老年食管鳞状细胞癌的疗效和安全性:一项前瞻性现实世界的实用研究

卷 23, 期 8, 2023

发表于: 27 April, 2023

页: [653 - 662] 页: 10

弟呕挨: 10.2174/1568009623666230315145937

价格: $65

摘要

背景：同步或最终放化疗是局部晚期食管鳞状细胞癌(ESCC)的标准治疗。老年患者因身体虚弱及多重合并症不能耐受标准同期化疗，接受放疗治疗。 目的：研究了同步(化疗)放疗联合尼莫单抗治疗老年ESCC患者的疗效和安全性。 方法; 符合条件的老年(≥70岁)局部晚期ESCC患者被纳入这项前瞻性、现实世界的实用研究，并接受同步放化疗或放疗联合尼莫单抗。主要终点是总生存期(OS)。次要终点为客观缓解率、疾病控制率、无进展生存期(PFS)和药物不良反应。 结果：纳入了53名老年患者。放疗联合尼莫单抗(RT+N) 32例(60.4%)，同步放化疗联合尼莫单抗(CRT+N) 21例(39.6%)。中位年龄为75.8岁。14例(56.0%)患者获得部分缓解，11例(44.0%)患者在3个月时病情稳定。中位随访时间为24.4个月(95%CI, 21.6-26.7)个月。中位OS (mOS)为27.0 (95%CI, 14.8-48.4)个月。中位PFS (mPFS)为22.6个月(95%CI, 12.4-未达到)。更高的mPFS(未达到vs. 12.0个月;p=0.022)和mOS (48.4 vs 15.3个月;p=0.009)，与RT+N组比较，CRT+N组有显著性差异。不良反应以1 ~ 2级为主(46.6%，86.8%)。 结论：在局部晚期ESCC老年患者中，同步放化疗或放疗联合尼莫单抗是安全且耐受性良好的。接受CRT+N治疗的ESCC患者寿命更长。

关键词: ESCC，尼莫单抗，老年患者，放化疗，总生存期，无进展生存期。

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