Title:Investigation of Airway Obstruction Severity Based on Plasma Visfatin
Level in Asthmatic Women
Volume: 19
Issue: 2
Author(s): Mitra Samareh Fekri, Seyed Mehdi Hashemi Bajgani, Mohsen Shafiepour, Reza Yazdani*Behnam Dalfardi
Affiliation:
- Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran
Keywords:
Airway obstruction, asthma, inflammation mediators, lung diseases, pulmonary function tests, visfatin
Abstract:
Introduction: Bronchial asthma is a chronic disorder with high prevalence among women.
Visfatin as a pro-inflammatory adipokine has been linked to inflammatory lung diseases such as
asthma and can be used as a forthcoming biomarker target to diagnose and treat asthmatic patients.
Aim: The aim of this study is to evaluate plasma visfatin level and its correlation with pulmonary
function of female asthmatic patients.
Methods: This cross-sectional study was conducted on all female asthmatic patients referred to the
Be'sat Pulmonary Clinic of Kerman from 1 November 2019 to 20 February 2020. Patients with confirmed
diagnosis of asthma were included. The data were collected through a checklist and the corresponding
author conducted all face-to-face interviews in the physician’s office of the pulmonary
clinic. Then, blood samples (5 cc) were taken from the patients to determine the plasma level of
visfatin. Data was analyzed by SPSS Software.
Results: 113 women with asthma were studied. The mean ± SD age of patients was 46.71 ± 13.91
years (range: 13 to 75). The mean ± SD of visfatin plasma levels was 26.30 ± 6.98 mg/dl (range:
8.50 to 46.88). The forced expiratory volume in the first second (FEV1) had a significant and negative
correlation with plasma visfatin concentrations (P-value = 0.03).
Conclusion: The results of this study indicated that plasma visfatin levels were correlated inversely
with FEV1 among asthmatic women. Further studies with large samples are recommended to evaluate
the role of visfatin in asthma pathogenesis.
