Title:New Insights into the Long Non-coding RNAs Dependent Modulation
of Heart Failure and Cardiac Hypertrophy: From Molecular
Function to Diagnosis and Treatment
Volume: 31
Issue: 11
Author(s): Malihe Rezaee, Niloufar Masihipour, Yaser Eshaghi Milasi, Rohollah Mousavi Dehmordi, Željko Reiner, Sepideh Asadi, Fatemeh Mohammadi, Parisa Khalilzadeh, Mehdi Rostami, Zatollah Asemi*Alireza Mafi*
Affiliation:
- Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
- Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences,
Isfahan University of Medical Sciences, Isfahan, Iran
- Nutrition and Food Security Research Center, Isfahan
University of Medical Sciences, Isfahan, Iran
Keywords:
Heart failure, long non-coding RNA, microRNA, molecular mechanism, biomarker, dyspnea.
Abstract: Heart failure (HF) is a public health issue that imposes high costs on healthcare
systems. Despite the significant advances in therapies and prevention of HF, it remains
a leading cause of morbidity and mortality worldwide. The current clinical diagnostic
or prognostic biomarkers, as well as therapeutic strategies, have some limitations.
Genetic and epigenetic factors have been identified to be central to the pathogenesis of
HF. Therefore, they might provide promising novel diagnostic and therapeutic approaches
for HF. Long non-coding RNAs (lncRNAs) belong to a group of RNAs that are produced
by RNA polymerase II. These molecules play an important role in the functioning
of different cell biological processes, such as transcription and regulation of gene expression.
LncRNAs can affect different signaling pathways by targeting biological molecules
or a variety of different cellular mechanisms. The alteration in their expression has been
reported in different types of cardiovascular diseases, including HF, supporting the theory
that they are important in the development and progression of heart diseases. Therefore,
these molecules can be introduced as diagnostic, prognostic, and therapeutic biomarkers
in HF. In this review, we summarize different lncRNAs as diagnostic, prognostic,
and therapeutic biomarkers in HF. Moreover, we highlight various molecular mechanisms
dysregulated by different lncRNAs in HF.
