Title:The Effect of Synthetic Curcumin Analogues on Obesity, Diabetes
and Cardiovascular Disease: A Literature Review
Volume: 30
Issue: 35
Author(s): Salime Lavian, Pegah Mardaneh, Mohammad Bagherniya*, Seyed Ahmad Emami, Alexandra E. Butler and Amirhossein Sahebkar*
Affiliation:
- Food Security Research Center, Isfahan University of Medical
Sciences, Isfahan, Iran
- Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences,
Isfahan, Iran
- Department of Community Nutrition, School of Nutrition and Food Science, Isfahan
University of Medical Sciences, Isfahan, Iran
- Applied Biomedical Research Center, Mashhad University of Medical Sciences,
Mashhad, Iran
- Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University
of Medical Sciences, Mashhad, Iran
- Department of Biotechnology, School of Pharmacy, Mashhad University
of Medical Sciences, Mashhad, Iran
Keywords:
Curcumin, synthetic analogue, obesity, diabetes, cardiovascular disease, treatment.
Abstract: Obesity, as an unfavorable consequence of our modern lifestyle, can promote
the emergence of other disorders, like diabetes and cardiovascular disease, that negatively
impact quality of life. Therefore, prevention and treatment of obesity and its related comorbidities
are critical. Lifestyle modification is the first and most important step but, in
practical terms, presents a major challenge to many patients. So, the development of new
strategies and therapies is critical for these patients. Although herbal bioactive compounds
have recently gained attention for their ability to prevent and treat conditions related
to obesity, no ideal pharmacological treatment has been found to treat obesity. Curcumin,
one of the compounds extracted from turmeric, is a well-studied active herbal extract;
however, its poor bioavailability and solubility in water, instability against temperature,
light and pH fluctuations and rapid excretion limit its therapeutic application. Curcumin
modification can, however, provide novel analogues with better performance and
fewer disadvantages in comparison to the original structure. In the past few years, the positive
effects of synthetic analogues of curcumin for the treatment of obesity, diabetes and
cardiovascular disorders have been reported. In this review, we evaluate the strengths
and weaknesses of the reported artificial derivatives and assess their practicality as therapeutic
agents.
