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Review Article

纳米微粒在癌症细胞中高效递送槲皮素的应用

卷 31, 期 9, 2024

发表于: 18 April, 2023

页: [1107 - 1141] 页: 35

弟呕挨: 10.2174/0929867330666230301121611

价格: $65

摘要

槲皮素（Qu，3,5,7,3'，4'-五羟基黄烷酮）是一种天然多酚化合物，广泛存在于健康食品或植物性产品中。近几十年来，屈因其广泛的有益治疗特性，如抗氧化、抗炎和抗癌活性，在食品、化妆品和制药行业引起了极大的关注。尽管Qu在癌症治疗中因其对细胞信号轴的众多影响而发挥着有利作用，但其化学稳定性和生物利用度差、水溶性低以及生物半衰期短，限制了其临床应用。最近，基于纳米技术的药物递送系统已经被开发出来，以克服这些限制，并在给药后增强曲的生物分布。多项研究表明，Qu的纳米制剂比其游离形式具有更显著的抗癌作用。此外，在各种纳米递送系统中加入曲可以提高其持续释放和稳定性，延长其循环时间，增强其在靶位点的积累，并提高其治疗效率。本研究的目的是对各种屈纳米制剂的抗癌特性进行全面综述，以增强其对不同恶性肿瘤的作用。本文讨论了改善Qu递送的各种靶向策略，包括纳米脂质体、脂质、聚合物、胶束和无机纳米颗粒NPs。目前的研究结果表明，将适当的纳米封装方法与肿瘤定向靶向递送相结合，可能会建立QU纳米颗粒，这可能是癌症治疗的一种有前途的技术。

关键词: 槲皮素，癌症，纳米颗粒，靶向递送，类黄酮，细胞凋亡。

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