Title:The Platelet Aggregation Inhibition Activity of Polyphenols can be Mediated
by 67kda Laminin Receptor: A New Therapeutic Strategy For the Treatment
of Venous Thromboembolism
Volume: 22
Issue: 1
Author(s): Satya Prakash, Amit Ghosh*, Arnab Nayek and Sheetal Kiran
Affiliation:
- Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
Keywords:
Laminin receptor, epigallocatechin gallate, EGCG, epigallocatechin, antiplatelet, polyphenols, flavonoids.
Abstract:
Background: Thrombotic disease is still a major killer. Aspirin, Ticagrelor, Clopidogrel,
etc. are the most widely used conventional antiplatelet drugs. The significant number of patients
who are resistant to this drug shows a poor outcome.
Objective: Developing a new antiplatelet agent with a stable antiplatelet effect and minimal
bleeding risk is required for a patient who is resistant to antiplatelet drugs.
Methods: Protein-ligand docking was performed using Autodock Vina 1.1.2 to study the interaction
of 67LR with different Polyphenols.
Results: Among the 18 polyphenols, thearubigin has the highest binding affinity towards 67LR and
gallic acid shows the lowest binding affinity. Among the 18 molecules, the top 4 molecules from the
highest to lowest binding affinity range from-10.6 (thearubigin) to -6.5 (Epigallocatechin).
Conclusion: Polyphenols may inhibit platelet aggregation through 67 LR and can be an alternative
treatment for Thrombotic Disease. Moreover, it will be interesting to know whether polyphenols
interfere with the same pathways as aspirin and clopidogrel. Effective polyphenols could help
prototype the compound development of novel antiplatelet agents.
