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Review Article

天然存在的黄酮；生物活性、化学特征和硅片药物发现

卷 31, 期 1, 2024

发表于: 19 May, 2023

页: [62 - 101] 页: 40

弟呕挨: 10.2174/0929867330666230221111941

价格: $65

Open Access Journals Promotions 2
摘要

氧杂蒽酮是分布广泛的多酚，普遍存在于高等植物中；藤黄果、海藻属、金丝桃属、柏拉图属、芒果属、龙胆属和獐牙菜属。氧杂蒽酮三环支架能够与不同的生物靶点相互作用，表现出抗菌和细胞毒作用，以及对骨关节炎、疟疾和心血管疾病的有效作用。因此，在本文中，我们重点关注 2017-2020 年 Xanthon 分离化合物的最新更新的药理作用、应用和临床前研究。我们发现只有α-山竹素、藤黄酸和芒果苷进行了临床前研究，特别强调抗癌、糖尿病、抗菌和保肝疗法的开发。进行分子对接计算以预测氧杂蒽酮衍生化合物对 SARS-CoV-2 Mpro 的结合亲和力。结果显示，角黄酮 E 和羊肚菌酸对 SARS-CoV-2 Mpro 表现出良好的结合亲和力，对接分数分别为 -11.2 和 -11.0 kcal/mol。结合特征表明角黄酮 E 和羊肚菌酸能够分别与 Mpro 活性位点的关键氨基酸形成九个和五个氢键。总之，角黄酮 E 和羊肚菌酸是有前景的抗 COVID-19 候选药物，值得进一步详细的体内实验评估和临床评估。

关键词: 黄酮,心血管保护,II期临床试验,生物活性,SARS-CoV-2主要蛋白,分子对接。

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