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Current Neuropharmacology

Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Review Article

Role of Circulating Exosomes in Cerebrovascular Diseases: A Comprehensive Review

Author(s): Zhiwen Lu, Haishuang Tang, Sisi Li, Shijie Zhu, Siqi Li and Qinghai Huang*

Volume 21, Issue 7, 2023

Published on: 14 February, 2023

Page: [1575 - 1593] Pages: 19

DOI: 10.2174/1570159X21666230214112408

Price: $65

Abstract

Exosomes are lipid bilayer vesicles that contain multiple macromolecules secreted by the parent cells and play a vital role in intercellular communication. In recent years, the function of exosomes in cerebrovascular diseases (CVDs) has been intensively studied. Herein, we briefly review the current understanding of exosomes in CVDs. We discuss their role in the pathophysiology of the diseases and the value of the exosomes for clinical applications as biomarkers and potential therapies.

Keywords: Exosome, cerebrovascular disease, biomarker, stroke, pathophysiology, therapy.

Graphical Abstract
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Vos, T.; Lim, S.S.; Abbafati, C.; Abbas, K.M.; Abbasi, M.; Abbasifard, M.; Abbasi-Kangevari, M.; Abbastabar, H.; Abd-Allah, F.; Abdelalim, A.; Abdollahi, M.; Abdollahpour, I.; Abolhassani, H.; Aboyans, V.; Abrams, E.M.; Abreu, L.G.; Abrigo, M.R.M.; Abu-Raddad, L.J.; Abushouk, A.I.; Acebedo, A.; Ackerman, I.N.; Adabi, M.; Adamu, A.A.; Adebayo, O.M.; Adekanmbi, V.; Adelson, J.D.; Adetokunboh, O.O.; Adham, D.; Afshari, M.; Afshin, A.; Agardh, E.E.; Agarwal, G.; Agesa, K.M.; Aghaali, M.; Aghamir, S.M.K.; Agrawal, A.; Ahmad, T.; Ahmadi, A.; Ahmadi, M.; Ahmadieh, H.; Ahmadpour, E.; Akalu, T.Y.; Akinyemi, R.O.; Akinyemiju, T.; Akombi, B.; Al-Aly, Z.; Alam, K.; Alam, N.; Alam, S.; Alam, T.; Alanzi, T.M.; Albertson, S.B.; Alcalde-Rabanal, J.E.; Alema, N.M.; Ali, M.; Ali, S.; Alicandro, G.; Alijanzadeh, M.; Alinia, C.; Alipour, V.; Aljunid, S.M.; Alla, F.; Allebeck, P.; Almasi-Hashiani, A.; Alonso, J.; Al-Raddadi, R.M.; Altirkawi, K.A.; Alvis-Guzman, N.; Alvis-Zakzuk, N.J.; Amini, S.; Amini-Rarani, M.; 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Gilani, S.A.; Gill, P.S.; Gitimoghaddam, M.; Giussani, G.; Goli, S.; Gomez, R.S.; Gopalani, S.V.; Gorini, G.; Gorman, T.M.; Gottlich, H.C.; Goudarzi, H.; Goulart, A.C.; Goulart, B.N.G.; Grada, A.; Grivna, M.; Grosso, G.; Gubari, M.I.M.; Gugnani, H.C.; Guimaraes, A.L.S.; Guimarães, R.A.; Guled, R.A.; Guo, G.; Guo, Y.; Gupta, R.; Haagsma, J.A.; Haddock, B.; Hafezi-Nejad, N.; Hafiz, A.; Hagins, H.; Haile, L.M.; Hall, B.J.; Halvaei, I.; Hamadeh, R.R.; Hamagharib Abdullah, K.; Hamilton, E.B.; Han, C.; Han, H.; Hankey, G.J.; Haro, J.M.; Harvey, J.D.; Hasaballah, A.I.; Hasanzadeh, A.; Hashemian, M.; Hassanipour, S.; Hassankhani, H.; Havmoeller, R.J.; Hay, R.J.; Hay, S.I.; Hayat, K.; Heidari, B.; Heidari, G.; Heidari-Soureshjani, R.; Hendrie, D.; Henrikson, H.J.; Henry, N.J.; Herteliu, C.; Heydarpour, F.; Hird, T.R.; Hoek, H.W.; Hole, M.K.; Holla, R.; Hoogar, P.; Hosgood, H.D.; Hosseinzadeh, M.; Hostiuc, M.; Hostiuc, S.; Househ, M.; Hoy, D.G.; Hsairi, M.; Hsieh, V.C.; Hu, G.; Huda, T.M.; Hugo, F.N.; 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