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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Research Article

通过综合生物信息学分析鉴定与肝细胞癌相关的药物靶点和药物

卷 23, 期 7, 2023

发表于: 21 March, 2023

页: [547 - 563] 页: 17

弟呕挨: 10.2174/1568009623666230214100159

价格: $65

摘要

背景：肝细胞癌（HCC）是全球癌症相关死亡的第三大原因。到目前为止，HCC发展的基础机制大多未知。 目的：本研究的主要目标是确定治疗HCC的潜在药物靶蛋白和药物。 方法：从NCBI-GEO数据库下载公开的三个独立的mRNA表达谱数据集，以使用统计LIMMA方法探索HCC和对照样品之间的共同差异表达基因（cDEG）。通过使用集成的生物信息学工具和数据库，确定了Hub-cDEG作为药物靶标，突出了其功能，途径和调节因子。最后，通过HCC分子对接研究鉴定了Hub-cDEGs引导的顶级药物。 结果：我们从三个独立的mRNA表达数据集中鉴定了160个常见的DEG（cDEG），其中10个cDEGs（CDKN3，TK1，NCAPG，CDCA5，RACGAP1，AURKA，PRC1，UBE2T，MELK和ASPM）被选为Hub-cDEGs。Hub-cDEG的GO功能和KEGG通路富集分析揭示了一些关键的癌症刺激生物过程、分子功能、细胞成分和信号通路。相互作用网络分析确定三种TF蛋白和5种miRNA是HubcDEG的关键转录和转录后调节因子。然后，我们检测到提出的Hub-cDEGs引导的排名靠前的三种抗HCC药物分子（放线菌素，长春新碱，西罗莫司），这些分子也得到了已经发表的顶级HCC引起的Hub-DEG介导受体的高度支持。 结论：本研究的结果将成为肝细胞癌诊断、预后和治疗的有用资源。

关键词: 肝细胞癌、差异表达基因 （DEG）、枢纽表达、药物靶标、药物制剂、综合生物信息学方法。

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