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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Mini-Review Article

Peptide-based Self-assembly: Design, Bioactive Properties, and Its Applications

Author(s): He Diao, Yunhua Lu, Yun Ling, Yingjie Shen, Jingmou Yu* and Kun Ma*

Volume 29, Issue 9, 2023

Published on: 20 February, 2023

Page: [640 - 651] Pages: 12

DOI: 10.2174/1381612829666230213152259

Price: $65

Abstract

The self-assembly of peptides is very popular in biomedical fields. Peptide-based assemblies have been used as an ideal candidate for drug/gene delivery, tissue engineering, and antibacterial/anticancer agents. The morphology and structure of peptide self-assembly can be changed by altering the molecular structure and the self-assembly conditions. Engineering peptide assemblies present great potential in medical fields. In this review, the structure and function of peptide self-assembly have been described. Also, the advances in peptide- based self-assembly have been highlighted in biomedical applications, such as drug packaging and delivery, tissue engineering, antibacterial agents, siRNA-targeted delivery and vaccines. Moreover, the challenges and future perspectives of the self-assembly of polypeptides are discussed.

Keywords: Peptides, self-assembly, biomedicine, drug delivery, tissue engineering, antibacterial agents.

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