Title:Cardioprotective Activities of some Indian Spices: An Insight into
Pharmacology and Phytochemical Investigation
Volume: 10
Issue: 1
Author(s): Kalyani Pathak*, Manash Pratim Pathak, Riya Saikia, Urvashee Gogoi, Jon Jyoti Sahariah, Aparoop Das, Mohammad Zaki Ahmad, Tirna Paul, Jyotirmoy Das and Saif Aboud M. Alqahtani
Affiliation:
- Department of Pharmaceutical Sciences, Dibrugarh University, Assam 786004, India
Keywords:
Indian spices, cardiovascular diseases, congestive heart failure, coronary heart disease, clinical trial, BP.
Abstract: Cardiovascular disease (CVD) is the leading cause of death globally, and coronary heart
disease (CHD) is the most prominent one among the spectrum of CVD. Conventional CHD drugs
pose an increased risk of pharmaceutical interactions. Moreover, the possibility of tainting or substituting
other medications also raises concerns. Diet and lifestyle play an important role in preventing
and treating heart disease, and certain spices and supplements can help reduce the risk of heart disease
and treat it. Spices have been an important part of Indian culture from the dawn of time, valued
for both their culinary and medicinal virtues. Indian spices and their bioactive phytoconstituents are
reported to play an ameliorating role in treating CHD. Despite the fact that the majority of these
spices have an effect on organic components associated with the cardiovascular system, data on
their therapeutic effects is sparse. To make the most of the enormous potential of these spices, multidisciplinary
research is the need of the hour to establish them as remedies for CVDs. We endeavour
to document some ethnopharmacological studies aimed to establish the cellular and molecular
cardio-protective mechanisms of the spices and their bioactive phytoconstituents using recently reported
in vitro and in vivo studies. Finally, we reviewed and reported the results of the recent clinical
trials that have been conducted using these spices with special emphasis on their efficacy, safety,
and toxicity.
