Title:An Approach to Treat Conundrum of Skin Cancer: Bioactive Loaded
Niosomes
Volume: 18
Issue: 4
Author(s): Shikha Srivastava*Divya Sharma
Affiliation:
- Institute of Pharmacy, Shri Ramswaroop Memorial University, Deva Road, Lucknow 225003, India
- Department of
Pharmacy, School of Medical and Allied Science, Galgotias University, Yamuna Expressway, Gautam Buddha Nagar,
Greater Noida, Uttar Pradesh, 201306, India
Keywords:
Skin cancer, quercetin, oxidative stress, niosomes, flavonoid, reactive oxygen species (ROS).
Abstract:
Background: Skin cancer is one of the most life-threatening and progressive diseases nowadays,
majorly resulting from the cumulative effect of genetic and environmental exposure including
UV rays and numerous pollutants. UV radiation stimulates the excessive generation of Reactive oxygen
species (ROS) and Reactive nitrogen species (RNS), altering numerous signaling and inflammatory
pathways and cumulatively causing alteration at numerous genetic and inflammatory levels. Numerous
treatment strategies have been proposed for this purpose, and it has been found that antioxidants
could play a crucial role in regulating inflammation at certain levels. Among numerous treatment
strategies, natural flavonoid quercetin could play a vital role in protecting cells from oxidative
stress as it is enriched with anticancer, antioxidant, and anti-inflammatory properties. The activities of
quercetin could be further enhanced by administrating it through novel systems.
Objective: Thus, the present article focuses on the delivery of natural flavonoid quercetin via novel
carrier noisome to enhance targeting potency and safety efficacy.
Method: Optimized quercetin-loaded niosomes were prepared by mechanical shaking method followed
by solvent evaporation and altering the ratio of cholesterol and span 80. In vitro characterization
was performed for morphology, zeta potential (ZP), entrapment efficiency and drug release.
Result: The optimized niosome was reported to have a size range of 120 nm, entrapment efficiency
(80%-85%) and followed zero order kinetics.
Conclusion: Optimized quercetin-loaded niosomes were successfully formulated and characterized
for controlled drug delivery.
