Title:Therapeutic Potential of Thiophene Compounds: A Mini-Review
Volume: 23
Issue: 15
Author(s): Shivani Chawla, Shweta Sharma, Sarfraj Kashid, Prabhakar Kumar Verma*Ashu Sapra
Affiliation:
- Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, Haryana, India
Keywords:
Thiophene, antimicrobial, anticancer, antioxidant, antituberculosis, gewald synthesis.
Abstract: A rising number of researchers are interested in thiophene-based analogs as they have wide
possibilities of biological potential in the largely developing chemical world of the heterocyclic moiety.
It also occupies a central position in synthetic organic chemistry and is of the highest theoretical
and practical importance. It became an important moiety for researchers to discover combinatorial
libraries and implement the efforts in search of the lead entity. Moreover, it helps medicinal chemists
to improve sophisticated molecules with a broad range of pharmacological activities. Thiophene and
its synthetic derivatives are a prominent heterocyclic compound class with intriguing uses in medical
chemistry. It has been manifesting to be an effective drug in current respective diseases scenario. It
has been discovered that thiophene had an extensive spectrum of pharmacological potential with numerous
applications in academic interest, in the pharmaceutical industry, material science, and medicinal
chemistry. Antimitotic, antimicrobial, anti-inflammatory, anticonvulsant, antipsychotic, antiarrhythmic,
anti-anxiety, antifungal, antioxidant, estrogen receptor regulating, and anti-cancer are one
of the pharmacological and physiological activities of thiophene moiety. However, there are some
marketed formulations available such as Thiophenfurin, Teniposide, Cefoxitin, Ticaconazole,
Sertaconazole, Suprofen, ketotifen, Brinzolamide, Dorzolamide, Tiotropium which contain thiophene
nucleus. Thus, in brief, gathering recent data is necessary to comprehend the present scenario of thiophene
moiety for scientific research purposes and highlights a broad view of the biological potential
of compounds having a thiophene nucleus.
