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Current Cardiology Reviews

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ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

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Review Article

Role of Gut Microbiome in Atherosclerosis: Molecular and Therapeutic Aspects

Author(s): Juan Salazar*, Valery Morillo, María K Suárez, Ana Castro, Paola Ramírez, Milagros Rojas, Roberto Añez, Luis D'Marco, Maricarmen Chacín-González and Valmore Bermúdez

Volume 19, Issue 4, 2023

Published on: 15 March, 2023

Article ID: e020223213408 Pages: 19

DOI: 10.2174/1573403X19666230202164524

Price: $65

Abstract

Atherosclerosis is one of the most relevant and prevalent cardiovascular diseases of our time. It is one of the pathological entities that increases the morbidity and mortality index in the adult population. Pathophysiological connections have been observed between atherosclerosis and the gut microbiome (GM), represented by a group of microorganisms that are present in the gut. These microorganisms are vital for metabolic homeostasis in humans. Recently, direct and indirect mechanisms through which GM can affect the development of atherosclerosis have been studied. This has led to research into the possible modulation of GM and metabolites as a new target in the prevention and treatment of atherosclerosis. The goal of this review is to analyze the physiopathological mechanisms linking GM and atherosclerosis that have been described so far. We also aim to summarize the recent studies that propose GM as a potential target in atherosclerosis management.

Keywords: Atherosclerosis, gut, microbiome, dysbiosis, inflammation, treatment.

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