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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Short Communication

微碎片化脂肪抑制小鼠间皮瘤异种移植的进展

卷 23, 期 8, 2023

发表于: 17 May, 2023

页: [663 - 668] 页: 6

弟呕挨: 10.2174/1568009623666230201092302

价格: $65

摘要

背景：恶性胸膜间皮瘤是一种没有有效治疗和预后差的病理。我们之前的研究表明，脂肪组织源性间充质基质细胞的裂解物和分泌组对间皮瘤细胞系有体外抑制作用。对肿瘤生长的抑制活性也在体内得到了证明:500万个间充质基质细胞“原位”注射，对MSTO-211H异种移植物产生了显著的治疗效果，相当于全身给药紫杉醇后观察到的效果。 目的：本研究的目的是评估少量(50万)间充质基质细胞和微碎片化脂肪组织(分离间充质基质细胞的生物组织)对间皮瘤细胞生长的影响。 方法：在体外和间皮瘤异种移植模型中评估肿瘤细胞的生长抑制。 结果：体外实验首次证实了脂肪组织微碎片脂肪对MSTO-211H细胞生长的抑制作用。然后评价微碎片化脂肪和少量间充质基质细胞对小鼠间皮瘤生长的抑制作用。我们的结果证实，“原位”注射的间充质基质细胞和微碎片脂肪都不会刺激间皮瘤细胞的生长。相比之下，微碎片化脂肪对肿瘤生长和进展产生了显著的抑制作用，与紫杉醇治疗所观察到的效果相当。少量间充质间质细胞仅发挥少量抗癌作用。 结论：微碎片脂肪在体外抑制间皮瘤细胞增殖，在体内对间皮瘤异种移植物生长有显著控制作用。

关键词: 间皮瘤，微碎片脂肪，间充质间质细胞，紫杉醇，异种移植物，脂肪组织。

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