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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

番茄红素作为一种潜在的生物活性化合物:化学、提取及抗癌前景

卷 23, 期 8, 2023

发表于: 27 February, 2023

页: [634 - 642] 页: 9

弟呕挨: 10.2174/1568009623666230131124236

价格: $65

摘要

番茄红素是一种潜在的生物活性物质，是一种非维生素a原类胡萝卜素，被认为是一种有效的抗氧化剂。它是从西红柿、西瓜、红胡萝卜和木瓜等植物中提取出来的，对健康有显著的好处。迄今为止，大量的研究已协助确定番茄红素的抗癌活性。我们的综述增加了有关该化合物具有抗癌潜力的信息。番茄红素在胰腺癌、乳腺癌、前列腺癌、肝癌、胃癌、卵巢癌、肾癌、皮肤癌、肠癌、脑癌和脊髓癌等方面的生物活性已在多项研究中得到描述。番茄红素通过抑制细胞凋亡、诱导细胞增殖、细胞侵袭、细胞周期发育、转移和血管生成来抵抗癌症。番茄红素的抗癌作用机制可能与调控胰岛素样生长因子系统、PI3K/Akt通路、修饰重要基因表达、抑制性类固醇激素活性、调控线粒体行为等信号转导途径有关。因此，本文就番茄红素的来源、提取技术、化学性质及其抗癌作用机制等方面的研究进展进行综述。综述了番茄红素的研究背景和最新研究进展，并对番茄红素在几种癌症治疗中的应用前景进行了展望。

关键词: 番茄红素，癌症治疗，类胡萝卜素，抗癌剂，萃取物，抗氧化剂。

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