Title:Status of α-emitter Radioimmunoconjugates for Targeted Therapy
Volume: 16
Issue: 2
Author(s): Rabiei Mobina, Ahmad Reza Vaez Alaei and Hassan Yousefnia*
Affiliation:
- Radiation Application Research School, Nuclear Science and Technology
Research Institute (NSTRI), Tehran, Iran
Keywords:
α-emitters, radio, immunotherapy, immunoconjugates, bifunctional ligands, trials.
Abstract: This minireview describes the global situation of ongoing research and development
and the clinical application of alpha emitter labeled immunoconjugates with various alpha emitters
with an overview of the future trends. The potentially helpful alpha emitter radioisotopes for
medical applications, chelators, and immunomolecules of interest for future alpha
radioimmunotherapy are discussed. Challenges and some suggested future works on chelators are
also presented.